HDDC3 抗体 (AA 25-179)
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Quick Overview for HDDC3 抗体 (AA 25-179) (ABIN7872846)
抗原
See all HDDC3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 25-179
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原理
- HDDC3 Antibody / HD domain-containing protein 3
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human HDDC3 recombinant protein (Position: K25-I179) was used as the immunogen for the HDDC3 antibody.
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亚型
- IgG
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anti-HD Domain Containing 3 (HDDC3) (AA 1-140) antibody
HDDC3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7E6 unconjugated
anti-HD Domain Containing 3 (HDDC3) (AA 2-140) antibodyHDDC3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-HD Domain Containing 3 (HDDC3) (C-Term) antibodyHDDC3 适用: 人, 小鼠, Cow, 豚鼠, 马, 犬, 斑马鱼, Pig, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the HDDC3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HDDC3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HDDC3 (HD Domain Containing 3 (HDDC3))
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别名
- HDDC3
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背景
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HDDC3 antibody detects HD domain-containing protein 3, a mitochondrial enzyme involved in NAD metabolism and stress-induced apoptosis regulation. The UniProt recommended name is HD domain-containing protein 3 (HDDC3). Also known as mitochondrial stress response protein MESH1, this enzyme exhibits NADPH phosphatase activity and modulates cellular redox state during stress adaptation.
Functionally, HDDC3 antibody identifies a 246-amino-acid protein localized to the mitochondrial matrix and cytoplasm. HDDC3 hydrolyzes NADPH to NADP+, regulating redox balance and reactive oxygen species production. It serves as a mammalian homolog of bacterial stringent response hydrolases, linking metabolic control to cell survival and autophagy.
The HDDC3 gene is located on chromosome 9q21.12 and is widely expressed, with highest levels in liver, kidney, and brain. Under oxidative or nutrient stress, HDDC3 modulates mitochondrial function, suppresses excessive NADPH accumulation, and contributes to redox homeostasis.
Pathologically, dysregulation of HDDC3 affects metabolic stress responses and apoptosis. Loss of function sensitizes cells to oxidative damage, while overexpression has been associated with tumor progression and altered NADPH signaling. Research using HDDC3 antibody supports studies in metabolism, mitochondrial dynamics, and cell death pathways.
HDDC3 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect NADPH-regulating enzymes. NSJ Bioreagents provides HDDC3 antibody reagents optimized for studies in mitochondrial metabolism, apoptosis, and redox biology.
Structurally, HD domain-containing protein 3 contains a conserved metal-dependent hydrolase domain that coordinates divalent cations for catalysis. This antibody enables analysis of HDDC3's enzymatic role in maintaining redox equilibrium and mitochondrial resilience. -
UniProt
- Q8N4P3
抗原
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