SPON1 抗体 (AA 247-611)
Our Local Distributor
北京 101111
Quick Overview for SPON1 抗体 (AA 247-611) (ABIN7872810)
抗原
See all SPON1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 247-611
-
原理
- SPON1 Antibody / Spondin 1
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human SPON1 recombinant protein (Position: E247-H611) was used as the immunogen for the SPON1 antibody.
-
亚型
- IgG
-
-
anti-Spondin 1 (SPON1) (AA 608-802) antibody
SPON1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Spondin 1 (SPON1) (AA 741-807) antibodySPON1 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Spondin 1 (SPON1) (AA 597-801) antibodySPON1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Spondin 1 (SPON1) (AA 15-43), (N-Term) antibodySPON1 适用: 小鼠, 人 WB, IHC (p) 宿主: 兔 Polyclonal RB18792 unconjugated
anti-Spondin 1 (SPON1) antibodySPON1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Spondin 1 (SPON1) antibodySPON1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Spondin 1 (SPON1) (AA 195-392) antibodySPON1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Spondin 1 (SPON1) (AA 14-44), (N-Term) antibodySPON1 适用: 小鼠, 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the SPON1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the SPON1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- SPON1 (Spondin 1 (SPON1))
-
别名
- SPON1
-
背景
-
SPON1 antibody detects Spondin-1, an extracellular matrix protein that promotes cell adhesion, axon guidance, and tissue organization. Spondin-1 is a member of the F-spondin family of secreted glycoproteins that regulate neuronal outgrowth and vascular patterning. The SPON1 antibody is used in neuroscience, developmental biology, and vascular research to study ECM signaling and neural development.
SPON1 is encoded by the SPON1 gene located on human chromosome 11p15.2. The protein is approximately 91 kilodaltons and consists of a signal peptide, reelin domain, thrombospondin type I repeats, and a C-terminal region that mediates cell surface binding. Spondin-1 is secreted into the extracellular matrix where it interacts with integrins and heparan sulfate proteoglycans to promote neurite extension and cell attachment.
A SPON1 antibody can detect a 90-95 kilodalton band by western blot and reveals extracellular and pericellular staining in immunohistochemistry. During embryonic development, Spondin-1 guides commissural axons across the midline and contributes to axonal fasciculation. In adult tissues, it participates in vascular remodeling and ECM integrity. Spondin-1 is also implicated in Alzheimer's disease pathology, where altered expression affects amyloid precursor protein processing.
Beyond neural function, Spondin-1 contributes to chondrogenesis, osteogenesis, and tumor angiogenesis. Its expression is upregulated during wound repair and inflammation, suggesting a role in tissue regeneration. NSJ Bioreagents provides a validated SPON1 antibody, supporting investigations into neuronal growth and extracellular signaling. -
UniProt
- Q9HCB6
抗原
-
