ITGA7 抗体 (AA 247-279)
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Quick Overview for ITGA7 抗体 (AA 247-279) (ABIN7872791)
抗原
See all ITGA7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 247-279
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原理
- Integrin alpha 7 Antibody / ITGA7
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 247-279 from the human protein was used as the immunogen for the Integrin alpha 7 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Integrin alpha 7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Integrin alpha 7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- ITGA7 (Integrin, alpha 7 (ITGA7))
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别名
- Integrin alpha 7
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背景
- Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
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UniProt
- Q13683
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途径
- Integrin Complex
抗原
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