STRN3 抗体 (AA 243-690)
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Quick Overview for STRN3 抗体 (AA 243-690) (ABIN7872774)
抗原
See all STRN3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 243-690
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原理
- STRN3 Antibody / Striatin 3
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human STRN3 recombinant protein (Position: D243-H690) was used as the immunogen for the STRN3 antibody.
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亚型
- IgG
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anti-Striatin, Calmodulin Binding Protein 3 (STRN3) (AA 200-460) antibody
STRN3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Striatin, Calmodulin Binding Protein 3 (STRN3) antibodySTRN3 适用: 小鼠, 人, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Striatin, Calmodulin Binding Protein 3 (STRN3) (AA 614-713) antibodySTRN3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3A5 unconjugated
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应用备注
- Optimal dilution of the STRN3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STRN3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STRN3 (Striatin, Calmodulin Binding Protein 3 (STRN3))
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别名
- STRN3
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背景
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STRN3 antibody detects Striatin-3, a calmodulin-binding scaffold protein that forms part of the striatin-interacting phosphatase and kinase (STRIPAK) complex. The UniProt recommended name is Striatin-3 (STRN3). This adaptor protein coordinates protein phosphatase 2A (PP2A) signaling and regulates cytoskeletal organization, cell migration, and signal transduction.
Functionally, STRN3 antibody identifies an 837-amino-acid protein that serves as a platform for assembling PP2A catalytic and regulatory subunits along with kinases such as MST3 and GCKIII family members. STRN3 modulates dephosphorylation of signaling proteins involved in cell adhesion, polarity, and morphogenesis. Its calmodulin-binding domain enables calcium-dependent regulation of complex formation.
The STRN3 gene is located on chromosome 14q12 and is expressed in various tissues, with particularly high levels in brain and heart. STRN3 participates in diverse signaling pathways, including the Hippo pathway, where it regulates MST1/2 kinase activity and contributes to growth control and organ size regulation. Its scaffold function allows spatial coordination between kinases and phosphatases within signaling microdomains.
Pathologically, aberrant STRN3 activity has been linked to cancer progression, cardiac hypertrophy, and neuronal dysfunction. Dysregulated STRIPAK signaling disrupts phosphorylation balance and cytoskeletal remodeling. STRN3 expression changes have been observed in glioblastoma and colon carcinoma, underscoring its importance in cell growth and motility.
STRN3 antibody is suitable for western blotting, immunofluorescence, and co-immunoprecipitation to identify PP2A-associated signaling complexes. NSJ Bioreagents provides validated STRN3 antibody reagents for research in kinase-phosphatase networks, cytoskeletal regulation, and signal transduction.
Structurally, Striatin-3 includes an N-terminal caveolin-binding motif, coiled-coil regions for oligomerization, a calmodulin-binding site, and WD-repeat domains for protein interactions. This antibody aids studies into STRN3's role as a scaffold coordinating phosphatase and kinase communication across multiple pathways. -
UniProt
- Q13033
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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