RAGE 抗体 (AA 24-52)
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Quick Overview for RAGE 抗体 (AA 24-52) (ABIN7872703)
抗原
See all RAGE (AGER) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 24-52
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原理
- AGER Antibody / RAGE
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纯化方法
- Antigen affinity
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免疫原
- A portion of amino acids 24-52 from the human protein was used as the immunogen for this AGER antibody.
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亚型
- Ig Fraction
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anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-237) antibody
AGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 180-402) antibodyAGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-404) antibodyAGER 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 151-250) antibodyAGER 适用: 人, 小鼠, 大鼠 WB, ELISA, IP, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-274) antibodyAGER 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-404) antibodyAGER 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C1 unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-120), (N-Term) antibodyAGER 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 76-104) antibodyAGER 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) antibody (Cy3)AGER 适用: 人, Cow WB, IHC, ELISA, ICC, IHC (p) 宿主: 小鼠 Monoclonal DD-A11 Cy3
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 29-59), (N-Term) antibodyAGER 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB04825-04826 unconjugated
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the AGER antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4oC for up to one month. For long term, aliquot the AGER antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
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别名
- AGER
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背景
- AGER is a cell surface receptor that is specifically activated by AGEs, which are formed when sugars react non-enzymatically with proteins or lipids. These AGEs are known to accumulate in various tissues over time, contributing to the development of complications like diabetic nephropathy, retinopathy, and neuropathy. AGER acts as a receptor for these AGEs, signaling pathways that lead to inflammation, oxidative stress, and tissue damage. Understanding the role of AGER in diabetes-related complications has significant implications for the development of novel therapeutic strategies. By targeting AGER and its downstream signaling pathways, researchers hope to mitigate the harmful effects of AGE accumulation in diabetic patients. In fact, recent studies have shown that blocking AGER with specific inhibitors can reduce inflammation and oxidative stress in diabetic animal models, offering promise for future treatments. In addition to its role in diabetes, AGER has also been implicated in other age-related diseases, such as Alzheimer's and cardiovascular disease. By studying the mechanisms by which AGER mediates these diseases, researchers can gain valuable insights into the underlying pathophysiology and identify new targets for intervention.
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UniProt
- Q15109
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途径
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
抗原
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