ATR 抗体 (AA 24-1324)
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Quick Overview for ATR 抗体 (AA 24-1324) (ABIN7872663)
抗原
See all ATR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 24-1324
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原理
- ATR Antibody / Ataxia telangiectasia and Rad3-related protein / FRP1
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids E24-D1324) was used as the immunogen for the ATR antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the ATR antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ATR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ATR (ATR serine/threonine kinase (ATR))
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别名
- ATR
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背景
- Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
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UniProt
- Q13535
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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