GHRHR 抗体 (AA 23-407)
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Quick Overview for GHRHR 抗体 (AA 23-407) (ABIN7872532)
抗原
See all GHRHR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-407
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原理
- GHRHR Antibody / Growth hormone releasing hormone receptor
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GHRHR recombinant protein (Position: H23-K407) was used as the immunogen for the GHRHR antibody.
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亚型
- IgG
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anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (C-Term) antibody
GHRHR 适用: 人, 大鼠, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (C-Term) antibodyGHRHR 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (AA 23-127) antibodyGHRHR 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (C-Term) antibodyGHRHR 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (AA 1-130) antibodyGHRHR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (AA 23-130) antibodyGHRHR 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (N-Term) antibodyGHRHR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (C-Term) antibodyGHRHR 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (AA 351-400) antibodyGHRHR 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone Releasing Hormone Receptor (GHRHR) (Cytoplasmic Domain) antibodyGHRHR 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GHRHR antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GHRHR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GHRHR (Growth Hormone Releasing Hormone Receptor (GHRHR))
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别名
- GHRHR
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背景
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GHRHR antibody detects Growth hormone releasing hormone receptor, encoded by the GHRHR gene. Growth hormone releasing hormone receptor is a G protein-coupled receptor expressed in the anterior pituitary, where it mediates responses to growth hormone releasing hormone. GHRHR antibody provides researchers with a tool to study endocrine signaling, growth regulation, and disease mechanisms involving pituitary hormone production.
Growth hormone releasing hormone receptor activates adenylate cyclase and cAMP signaling pathways upon binding its ligand. Research using GHRHR antibody has shown that this activation stimulates growth hormone synthesis and secretion. Growth hormone then regulates somatic growth, metabolism, and tissue repair through downstream IGF-1 production. This axis is essential for normal growth and metabolic homeostasis.
Studies with GHRHR antibody have revealed that mutations in GHRHR cause isolated growth hormone deficiency. This condition is characterized by short stature, delayed growth, and impaired metabolic adaptation. Mutations that disrupt receptor folding, trafficking, or signaling result in insufficient growth hormone production, demonstrating the receptor's critical physiological role.
Beyond growth deficiency, dysregulation of GHRHR signaling contributes to endocrine disease and cancer. Research using GHRHR antibody has shown that receptor variants are expressed in tumors such as pituitary adenomas and certain carcinomas. Aberrant signaling through GHRHR promotes proliferation and survival, linking it to oncogenic pathways. These findings highlight GHRHR as both a diagnostic marker and a potential therapeutic target.
GHRHR antibody is widely used in immunohistochemistry, western blotting, and receptor binding assays. Immunohistochemistry highlights expression in pituitary tissue, western blotting quantifies receptor levels, and binding studies confirm functional activity. These applications make GHRHR antibody indispensable in endocrinology and oncology research.
By providing validated GHRHR antibody reagents, NSJ Bioreagents supports studies into pituitary signaling, growth hormone regulation, and disease. Detection of Growth hormone releasing hormone receptor provides researchers with insights into how endocrine pathways control growth and metabolism. -
UniProt
- Q02643
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Hormone Transport, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process
抗原
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