STK38L 抗体 (AA 23-370)
Our Local Distributor
北京 101111
Quick Overview for STK38L 抗体 (AA 23-370) (ABIN7872529)
抗原
See all STK38L 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 23-370
-
原理
- Zebrafish Ndr2 Antibody / Cyclops / Nodal-related 2 precursor
-
纯化方法
- Antigen affinity chromatography
-
免疫原
- E. coli-derived zebrafish Ndr2 recombinant protein (amino acids K23-R370) was used as the immunogen for the Zebrafish Ndr2 antibody.
-
亚型
- Ig Fraction
-
-
anti-serine/threonine Kinase 38 Like (STK38L) (AA 1-281) antibody
STK38L 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4D8 unconjugated
anti-serine/threonine Kinase 38 Like (STK38L) (AA 212-464) antibodySTK38L 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 38 Like (STK38L) (AA 1-464) antibodySTK38L 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4E5 unconjugated
anti-serine/threonine Kinase 38 Like (STK38L) (AA 1-281) antibodySTK38L 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-serine/threonine Kinase 38 Like (STK38L) (AA 165-464) antibodySTK38L 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 38 Like (STK38L) (AA 408-437), (C-Term) antibodySTK38L 适用: 人 WB 宿主: 兔 Polyclonal RB9195 unconjugated
anti-serine/threonine Kinase 38 Like (STK38L) (C-Term) antibodySTK38L 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 38 Like (STK38L) (AA 1-464) antibodySTK38L 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-serine/threonine Kinase 38 Like (STK38L) antibodySTK38L 适用: 人 DB 宿主: 小鼠 Monoclonal 3563C2a unconjugated
anti-serine/threonine Kinase 38 Like (STK38L) (AA 212-464) antibodySTK38L 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7B12B3 unconjugated
-
-
应用备注
- Optimal dilution of the Zebrafish Ndr2 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the Zebrafish Ndr2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- STK38L (serine/threonine Kinase 38 Like (STK38L))
-
别名
- Ndr2
-
背景
-
Ndr2, also called Nodal related protein 2 and Cyclops, is a secreted signaling molecule that belongs to the transforming growth factor beta superfamily. In zebrafish, Ndr2 plays an essential role in early embryonic development, particularly in the formation of mesoderm and endoderm, and in the establishment of the embryonic body axes. It functions through the Nodal signaling pathway, which regulates gene expression patterns necessary for germ layer differentiation and left right asymmetry.
Zebrafish Ndr2 is closely related in function to the human NODAL protein. While it is not a direct one to one ortholog due to gene duplication events in zebrafish, Ndr2 and human NODAL share conserved domains and activate similar signaling cascades through type one and type two serine threonine kinase receptors and intracellular SMAD transcription factors. Both proteins are tightly regulated by extracellular antagonists such as Lefty and intracellular feedback loops.
In zebrafish embryos, Ndr2 is expressed during gastrulation and is critical for the induction of the organizer region and patterning of the mesendoderm. Disruption of Ndr2 results in severe developmental defects, including failure to form the embryonic axis and internal organs. Because of its functional conservation with human NODAL and its central role in vertebrate development, zebrafish Ndr2 is widely used as a model to study signaling pathways involved in embryogenesis, tissue specification, and congenital malformations.
-
UniProt
- P87358
抗原
-
