THEM6 抗体 (AA 23-208)
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Quick Overview for THEM6 抗体 (AA 23-208) (ABIN7872503)
抗原
See all THEM6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-208
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原理
- THEM6 Antibody / Thioesterase superfamily member 6
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human THEM6 recombinant protein (Position: Y23-Q208) was used as the immunogen for the THEM6 antibody.
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亚型
- IgG
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anti-Mesenchymal Stem Cell Protein DSCD75 (THEM6) (Internal Region) antibody
THEM6 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Mesenchymal Stem Cell Protein DSCD75 (THEM6) (AA 200-250) antibodyTHEM6 适用: 人, 猴 WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Mesenchymal Stem Cell Protein DSCD75 (THEM6) (N-Term) antibodyTHEM6 适用: 人 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the THEM6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the THEM6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- THEM6 (Mesenchymal Stem Cell Protein DSCD75 (THEM6))
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别名
- THEM6
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背景
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THEM6 antibody detects Acyl-CoA thioesterase THEM6, a lipid-metabolizing enzyme that hydrolyzes fatty acyl-CoA esters to free fatty acids and CoA, regulating lipid signaling and energy homeostasis. The UniProt recommended name is Acyl-CoA thioesterase THEM6 (THEM6). This enzyme belongs to the thioesterase superfamily, which plays essential roles in lipid metabolism, peroxisomal function, and cellular stress response.
Functionally, THEM6 antibody identifies a 247-amino-acid protein localized primarily in the endoplasmic reticulum (ER). THEM6 catalyzes the hydrolysis of long-chain acyl-CoA molecules, controlling intracellular levels of activated fatty acids and maintaining the balance between lipid synthesis and degradation. By regulating acyl-CoA and free fatty acid pools, THEM6 influences energy metabolism, membrane composition, and lipid signaling cascades.
The THEM6 gene is located on chromosome 1p36.33 and encodes an enzyme expressed in metabolically active tissues, including liver, adipose tissue, and skeletal muscle. THEM6 contains a hotdog-fold thioesterase domain characteristic of enzymes that process acyl-CoA intermediates. Its activity is critical for preventing the accumulation of toxic acyl-CoA derivatives that can impair mitochondrial function and oxidative metabolism. THEM6 also participates in lipid remodeling pathways that maintain ER membrane homeostasis.
In cellular metabolism, THEM6 acts as a regulator of lipid droplet dynamics and fatty acid oxidation. It modulates the availability of CoA for beta-oxidation and phospholipid biosynthesis, indirectly influencing mitochondrial energy production. Dysregulation of THEM6 expression has been linked to metabolic disorders, including fatty liver disease and obesity. Emerging evidence suggests a role for THEM6 in cancer cell metabolism, where enhanced lipid turnover supports rapid proliferation and membrane biogenesis.
THEM6 antibody is widely used in lipid metabolism, enzymology, and metabolic disease research. It is suitable for western blotting, immunofluorescence, and subcellular localization studies to detect THEM6 expression in cellular and tissue samples. This antibody supports studies of acyl-CoA metabolism, lipid homeostasis, and ER stress responses. In metabolic and cancer research, THEM6 detection provides insights into how cells reprogram lipid utilization under stress or nutrient limitation.
Structurally, THEM6 contains a conserved thioesterase catalytic triad composed of serine, histidine, and aspartate residues, mediating acyl-CoA hydrolysis. Its ER localization is maintained through a C-terminal retention signal, and its expression may be regulated by nutrient and hormonal cues. NSJ Bioreagents provides THEM6 antibody reagents validated for use in lipid signaling, metabolic regulation, and enzymatic function research. -
UniProt
- Q8WUY1
抗原
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