NCOR1 抗体 (AA 23-2075)
Our Local Distributor
北京 101111
Quick Overview for NCOR1 抗体 (AA 23-2075) (ABIN7872502)
抗原
See all NCOR1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 23-2075
-
原理
- NCOR1 Antibody / Nuclear receptor corepressor 1
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human NCOR1 recombinant protein (Position: H23-Q2075) was used as the immunogen for the NCOR1 antibody.
-
亚型
- IgG
-
-
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 1-200) antibody
NCOR1 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (N-Term) antibodyNCOR1 适用: 人, 小鼠 ELISA, IHC, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 1-192) antibodyNCOR1 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 7A7A9 unconjugated
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 16-47), (N-Term) antibodyNCOR1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB2594 unconjugated
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 484-533) antibodyNCOR1 适用: 人, 小鼠, Cow, Bat IHC, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (N-Term) antibodyNCOR1 适用: 人, 小鼠, 犬 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (N-Term) antibodyNCOR1 适用: 人, 小鼠 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 2341-2440) antibodyNCOR1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) antibodyVerified NCOR1 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 1770-1947) antibodyNCOR1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the NCOR1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the NCOR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))
-
别名
- NCOR1
-
背景
-
NCOR1 antibody detects Nuclear receptor corepressor 1, a transcriptional regulator that mediates repression of gene expression by nuclear hormone receptors and other transcription factors. The UniProt recommended name is Nuclear receptor corepressor 1 (NCOR1), with alternate names including nuclear receptor co-repressor, thyroid hormone receptor-interacting protein 13 (TRAC13), and retinoic acid receptor-binding protein. NCOR1 functions as a scaffold protein that bridges transcription factors with histone deacetylases (HDACs), leading to chromatin condensation and transcriptional silencing.
Functionally, NCOR1 antibody recognizes a large nuclear protein (~270 kDa) that forms complexes with histone deacetylase 3 (HDAC3) and transducin beta-like proteins (TBL1X, TBL1XR1), serving as the catalytic core of the NCOR/SMRT repression complex. NCOR1 regulates gene networks responsive to thyroid hormone, retinoic acid, glucocorticoids, and other ligands by recruiting HDAC3 to promoter regions. Through its receptor-interacting domains, NCOR1 binds unliganded nuclear receptors such as TR, RAR, and RXR to maintain basal transcriptional repression. Upon ligand binding, corepressors are released, and coactivators are recruited to enable gene activation.
In developmental and metabolic regulation, NCOR1 influences adipogenesis, gluconeogenesis, circadian rhythm, and immune cell differentiation. Deletion of NCOR1 in adipose tissue leads to increased mitochondrial activity and energy expenditure, highlighting its role in metabolic homeostasis. In neurons, NCOR1 modulates synaptic plasticity and behavior by repressing neural gene programs. Overexpression or mutation of NCOR1 can disrupt transcriptional balance and contribute to diseases including cancer, metabolic syndrome, and neurodevelopmental disorders. For example, NCOR1 loss correlates with enhanced oncogenic signaling in breast and prostate cancer models.
Structurally, NCOR1 contains multiple repression domains, nuclear receptor interaction motifs (L/IxxI/VI), and coiled-coil regions that enable interaction with HDAC3 and transcription factors. The NCOR1 antibody is widely used in chromatin immunoprecipitation (ChIP), western blotting, and immunofluorescence assays to examine chromatin binding, nuclear localization, and HDAC recruitment. The NCOR1 gene is located on chromosome 17p12 and encodes a 2453-amino acid protein conserved across mammals. It shares functional similarity with NCOR2 (SMRT), though the two exhibit distinct expression profiles and complex-specific functions.
By targeting a master regulator of transcriptional repression, NCOR1 antibody supports research in gene regulation, epigenetics, and signal-dependent chromatin remodeling. NSJ Bioreagents provides validated reagents for human, mouse, and rat NCOR1 detection across multiple experimental platforms for transcriptional and chromatin research. -
UniProt
- O75376
-
途径
- Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process
抗原
-
