DERL1 抗体 (AA 224-251)
Our Local Distributor
北京 101111
Quick Overview for DERL1 抗体 (AA 224-251) (ABIN7872381)
抗原
See all DERL1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 224-251
-
原理
- Derlin 1 Antibody / DERL1
-
纯化方法
- Antigen affinity purified
-
免疫原
- A portion of amino acids 224-251 from the human protein was used as the immunogen for the Derlin 1 antibody.
-
亚型
- Ig Fraction
-
-
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 224-251), (C-Term) antibody
DERL1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22770 unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 111-220) antibodyDERL1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 224-251) antibodyDERL1 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 222-251), (C-Term) antibodyDERL1 适用: 人, 小鼠 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 201-251) antibodyDERL1 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 200-251), (C-Term) antibodyDERL1 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- The stated application concentrations are suggested starting points. Titration of the Derlin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the Derlin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
-
别名
- Derlin 1
-
背景
- Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
-
UniProt
- Q9BUN8
-
途径
- ER-Nucleus Signaling
抗原
-
