Recombinant PAX2A 抗体 (AA 223-354)
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Quick Overview for Recombinant PAX2A 抗体 (AA 223-354) (ABIN7872377)
抗原
See all PAX2A 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 223-354
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原理
- PAX2 Antibody (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein (within amino acids 223-354) from the human protein was used as the immunogen for the PAX2 antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the PAX2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the PAX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- PAX2A (Paired Box Gene 2a (PAX2A))
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别名
- PAX2
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背景
- Recognizes a protein of 42 kDa, which is identified as PAX2. It is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mullerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms' tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.
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UniProt
- Q02962
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途径
- Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation
抗原
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