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Splicing Factor 1 抗体 (AA 220-461)

The 小鼠 单克隆 anti-Splicing Factor 1 antibody is suitable to detect Splicing Factor 1 in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7872351
发货至: 中国
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Quick Overview for Splicing Factor 1 抗体 (AA 220-461) (ABIN7872351)

抗原

See all Splicing Factor 1 (SF1) 抗体
Splicing Factor 1 (SF1)

适用

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宿主

  • 76
  • 8
小鼠

克隆类型

  • 72
  • 12
单克隆

标记

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This Splicing Factor 1 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

NR5A1-3420
  • 抗原表位

    • 29
    • 9
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
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    • 1
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    • 1
    AA 220-461

    原理

    SF-1 Antibody / Steroidogenic Factor 1 / NR5A1

    纯化方法

    Protein A/G affinity

    免疫原

    A portion of amino acids 220-461 was used as the immunogen for the SF-1 antibody.

    亚型

    IgG2b, kappa
  • 应用备注

    Optimal dilution of the Steroidogenic Factor 1 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the Steroidogenic Factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    Splicing Factor 1 (SF1)

    别名

    SF-1

    背景

    The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. Steroidogenic Factor 1 (SF-1) is considered an orphan nuclear receptor that belongs to subfamily 5. It was found to be a regulator of steroidogenic enzyme gene expression. Oxysterols are suggested as its ligands. It is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF-1 plays an important role in adrenal and gonadal development. SF-1 is highly valuable marker to determine the adrenocortical origin of an adrenal mass.

    UniProt

    Q13285

    途径

    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Maintenance of Protein Location
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