PPP1R15B 抗体 (AA 211-657)
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Quick Overview for PPP1R15B 抗体 (AA 211-657) (ABIN7872192)
抗原
See all PPP1R15B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 211-657
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原理
- PPP1R15B Antibody / Protein phosphatase 1 regulatory subunit 15B
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids Q211-D657) was used as the immunogen for the PPP1R15B antibody.
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亚型
- IgG
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anti-Protein Phosphatase 1, Regulatory Subunit 15B (PPP1R15B) (AA 494-522), (C-Term) antibody
PPP1R15B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32305 unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 15B (PPP1R15B) (AA 480-529) antibodyPPP1R15B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 15B (PPP1R15B) (Internal Region) antibodyPPP1R15B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PPP1R15B antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PPP1R15B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PPP1R15B (Protein Phosphatase 1, Regulatory Subunit 15B (PPP1R15B))
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别名
- PPP1R15B
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背景
- PPP1R15B (Protein phosphatase 1, regulatory subunit 15b), also called CREP, promotes dephosphorylation of the transcription initiation factor EIF2-alpha through recruitment of protein phosphatase-1(PP1) catalytic subunits. The PPP1R15B gene is mapped to chromosome 1q32.1 based on an alignment of thePPP1R15B sequence by Hartz(2010). Harding et al.(2009) obtained Ppp1r15b -/- mice at a mendelian ratio. However, Ppp1r15b -/- newborns were half the size of their wildtype littermates, were notably pale, and failed to nurse, and none survived the first day of postnatal life. Ppp1r15b -/- embryos that were also homozygous for an Eif2-alpha mutation that prevented Eif2-alpha phosphorylation were normalized, including elevated birth size and restored red blood cell count, compared with Ppp1r15b -/- embryos with wildtype Eif2-alpha.
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UniProt
- Q5SWA1
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途径
- ER-Nucleus Signaling
抗原
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