LY6D 抗体 (AA 21-111)
The 兔 多克隆 anti-LY6D antibody is suitable to detect LY6D in samples from 人. It has been validated for ELISA, WB 和 IHC.
产品编号 ABIN7872120
发货至:
中国
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Quick Overview for LY6D 抗体 (AA 21-111) (ABIN7872120)
抗原
See all LY6D 抗体
LY6D
(Lymphocyte Antigen 6 Complex, Locus D (LY6D))
适用
人
宿主
兔
克隆类型
多克隆
标记
This LY6D antibody is un-conjugated
应用范围
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
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抗原表位
- AA 21-111
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原理
- LY6D Antibody / Lymphocyte antigen 6D
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human LY6D recombinant protein (Position: L21-L111) was used as the immunogen for the LY6D antibody.
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亚型
- IgG
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anti-Lymphocyte Antigen 6 Complex, Locus D (LY6D) (AA 21-128) antibody
LY6D 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Lymphocyte Antigen 6 Complex, Locus D (LY6D) (AA 1-128) antibodyLY6D 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the LY6D antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the LY6D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- LY6D (Lymphocyte Antigen 6 Complex, Locus D (LY6D))
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别名
- LY6D
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背景
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LY6D antibody detects Lymphocyte antigen 6D, encoded by the LY6D gene. Lymphocyte antigen 6D is a glycosylphosphatidylinositol-anchored cell surface protein of the LY6/uPAR family, expressed in epithelial cells and lymphoid precursors. LY6D antibody provides researchers with a specific reagent for studying epithelial differentiation, lymphoid specification, and cancer biology.
Lymphocyte antigen 6D belongs to a family of GPI-anchored proteins characterized by the LY6/uPAR domain. Research using LY6D antibody has shown that it is expressed in epithelial cells of skin and mucosa, where it contributes to barrier formation and differentiation. In the hematopoietic system, LY6D marks early B cell precursors and distinguishes B lineage commitment from alternative lymphoid fates.
Studies with LY6D antibody have revealed that LY6D serves as a robust marker of B cell development in both mice and humans. Expression of LY6D indicates initiation of the B cell program, allowing identification of common lymphoid progenitors committed to B lineage. This makes LY6D antibody an important tool for immunology research and flow cytometric analysis of hematopoiesis.
Dysregulation of Lymphocyte antigen 6D has been associated with cancer and immune disorders. Research using LY6D antibody has shown that it is overexpressed in squamous cell carcinomas of head, neck, and esophagus, where it promotes tumor growth and invasion. In addition, LY6D has been proposed as a diagnostic biomarker and potential therapeutic target in epithelial cancers. Its expression in immune precursors also makes it relevant in studies of immune reconstitution and leukemia.
LY6D antibody is widely applied in flow cytometry, immunohistochemistry, and western blotting. Flow cytometry identifies B lineage progenitors, immunohistochemistry highlights epithelial expression in normal and tumor tissues, and western blotting quantifies levels across developmental and disease states. These applications make LY6D antibody indispensable for immunology and cancer research.
By providing validated LY6D antibody reagents, NSJ Bioreagents supports studies into epithelial differentiation, B cell biology, and cancer. Detection of Lymphocyte antigen 6D provides researchers with insight into how cell surface antigens regulate immunity and tumor progression. -
UniProt
- Q14210
抗原
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