MYORG/KIAA1161 抗体 (AA 207-611)
The 兔 多克隆 anti-MYORG/KIAA1161 antibody is suitable to detect MYORG/KIAA1161 in samples from 人, 小鼠 和 大鼠. It has been validated for ELISA, WB 和 FACS.
产品编号 ABIN7872108
发货至:
中国
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Quick Overview for MYORG/KIAA1161 抗体 (AA 207-611) (ABIN7872108)
抗原
See all MYORG/KIAA1161 (MYORG) 抗体
MYORG/KIAA1161 (MYORG)
(Myogenesis Regulating Glycosidase (MYORG))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This MYORG/KIAA1161 antibody is un-conjugated
应用范围
ELISA, Western Blotting (WB), Flow Cytometry (FACS)
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抗原表位
- AA 207-611
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原理
- MYORG Antibody / Myogenesis-regulating glycosidase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MYORG recombinant protein (Position: Q207-R611) was used as the immunogen for the MYORG antibody.
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亚型
- IgG
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anti-Myogenesis Regulating Glycosidase (MYORG) (AA 101-300) antibody
MYORG 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the MYORG antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MYORG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MYORG/KIAA1161 (MYORG) (Myogenesis Regulating Glycosidase (MYORG))
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别名
- MYORG
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背景
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MYORG antibody detects Myogenesis-regulating glycosidase, a lysosomal and endoplasmic reticulum-associated enzyme involved in protein processing and neurological function. The UniProt recommended name is Myogenesis-regulating glycosidase (MYORG). This glycosidase is highly conserved and plays a crucial role in the maintenance of glycoprotein homeostasis within neural tissues, particularly astrocytes.
Functionally, MYORG antibody identifies a 714-amino-acid glycosidase belonging to the glycosyl hydrolase family 31. MYORG hydrolyzes terminal sugar residues from oligosaccharides and glycoproteins, participating in lysosomal degradation and protein quality control. It is mainly localized to the endoplasmic reticulum and perinuclear regions, suggesting involvement in post-translational processing rather than extracellular digestion.
The MYORG gene is located on chromosome 9p13.1 and is highly expressed in brain and skeletal muscle. In the central nervous system, MYORG supports astrocyte differentiation and intercellular communication. It is co-regulated with genes controlling lysosomal activity, endoplasmic reticulum homeostasis, and metabolic signaling.
Pathologically, mutations in MYORG cause primary familial brain calcification (PFBC), a neurodegenerative disorder characterized by calcium deposits in basal ganglia and cerebellum. Deficiency in MYORG leads to altered glycosylation and impaired protein turnover in astrocytes. Research using MYORG antibody assists studies of glycoprotein metabolism, lysosomal function, and neurological disease mechanisms.
MYORG antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect intracellular glycosidases and neuronal processing enzymes. NSJ Bioreagents provides MYORG antibody reagents optimized for neuroscience, enzymology, and cellular metabolism research.
Structurally, Myogenesis-regulating glycosidase contains a catalytic domain typical of glycosyl hydrolases with conserved acid-base residues, and a C-terminal transmembrane region anchoring it to intracellular membranes. This antibody supports analysis of MYORG's biochemical function and contribution to neurodegenerative disorders. -
UniProt
- Q6NSJ0
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途径
- Skeletal Muscle Fiber Development
抗原
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