SMPD1 抗体 (AA 204-558)
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Quick Overview for SMPD1 抗体 (AA 204-558) (ABIN7872093)
抗原
See all SMPD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 204-558
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原理
- aSMase Antibody / Smpd1 / Acid sphingomyelinase
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant mouse protein (amino acids D204-M558) was used as the immunogen for the aSMase antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the aSMase antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the aSMase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))
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别名
- aSMase
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背景
- Sphingomyelin phosphodiesterase 1 (SMPD1), also known as acid sphingomyelinase (ASM or aSMase), is an enzyme that in humans is encoded by the SMPD1 gene. Enables acid sphingomyelin phosphodiesterase activity and zinc ion binding activity. Involved in ceramide biosynthetic process, positive regulation of apoptotic process, and response to ionizing radiation. Acts upstream of or within ceramide metabolic process, cholesterol metabolic process, and sphingomyelin catabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system, integumental system, nervous system, sensory organ, and skeleton. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease, Niemann-Pick disease type A, and Niemann-Pick disease type B. Orthologous to human SMPD1 (sphingomyelin phosphodiesterase 1).
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UniProt
- Q04519
抗原
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