PTCD1 抗体 (AA 203-601)
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Quick Overview for PTCD1 抗体 (AA 203-601) (ABIN7872087)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 203-601
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原理
- PTCD1 Antibody / Pentatricopeptide repeat domain-containing protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human PTCD1 recombinant protein (Position: D203-L601) was used as the immunogen for the PTCD1 antibody.
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亚型
- IgG
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anti-Pentatricopeptide Repeat Domain 1 (PTCD1) (AA 435-537) antibody
PTCD1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Pentatricopeptide Repeat Domain 1 (PTCD1) antibodyPTCD1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Pentatricopeptide Repeat Domain 1 (PTCD1) (AA 51-100) antibodyPTCD1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Pentatricopeptide Repeat Domain 1 (PTCD1) (N-Term) antibodyPTCD1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PTCD1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PTCD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PTCD1 (Pentatricopeptide Repeat Domain 1 (PTCD1))
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别名
- PTCD1
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背景
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PTCD1 antibody detects Pentatricopeptide repeat domain-containing protein 1, a mitochondrial RNA-binding protein that regulates mitochondrial gene expression and RNA metabolism. Encoded by the PTCD1 gene on chromosome 2q31.3, this protein contains multiple tandem pentatricopeptide repeat (PPR) motifs that mediate specific binding to mitochondrial RNA transcripts. PTCD1 functions as a post-transcriptional regulator that controls the stability, processing, and translation of mitochondrial mRNAs essential for oxidative phosphorylation. By coordinating RNA maturation and ribosome assembly within mitochondria, PTCD1 ensures proper energy production and cellular respiration.
PTCD1 belongs to a large family of PPR proteins that are characterized by their modular RNA-binding repeats. In mammalian cells, PTCD1 localizes to the mitochondrial matrix and associates with mitochondrial ribonucleoprotein complexes. Functional studies indicate that PTCD1 modulates expression of key mitochondrial-encoded subunits of the respiratory chain, including components of complexes I and IV. Knockdown or loss of PTCD1 disrupts mitochondrial translation, leading to impaired ATP synthesis and increased reactive oxygen species production. As such, PTCD1 plays a central role in maintaining mitochondrial integrity and energy homeostasis.
The PTCD1 antibody is widely used in studies of mitochondrial biology, RNA processing, and metabolic regulation. In western blot assays, PTCD1 is detected as a ~75 kilodalton band, while immunofluorescence reveals punctate staining consistent with mitochondrial localization. Expression profiling has shown that PTCD1 is abundant in metabolically active tissues such as heart, skeletal muscle, and brain, where mitochondrial activity is high. The antibody is an essential reagent for examining mitochondrial gene expression pathways and for identifying alterations in mitochondrial function associated with metabolic disorders and neurodegeneration.
Beyond its core function in RNA metabolism, PTCD1 has been linked to mitochondrial-nuclear communication and apoptosis regulation. It may influence the transcription of nuclear-encoded mitochondrial genes by modulating signaling pathways that respond to mitochondrial dysfunction. Genetic variants of PTCD1 have been associated with susceptibility to metabolic diseases, including type 2 diabetes and mitochondrial encephalomyopathy. The PTCD1 antibody thus enables researchers to explore these regulatory networks and to define the molecular mechanisms that couple RNA metabolism with mitochondrial biogenesis. NSJ Bioreagents provides this antibody validated for its applications, supporting studies in bioenergetics, RNA regulation, and mitochondrial pathophysiology. -
UniProt
- O75127
抗原
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