DBH 抗体 (AA 200-400)
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Quick Overview for DBH 抗体 (AA 200-400) (ABIN7872013)
抗原
See all DBH 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 200-400
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原理
- Dopamine Beta-Hydroxylase Antibody / DBH
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the Dopamine Beta-Hydroxylase antibody.
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亚型
- IgG2, kappa
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应用备注
- Optimal dilution of the Dopamine Beta-Hydroxylase antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Dopamine Beta-Hydroxylase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))
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别名
- Dopamine Beta-Hydroxylase
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背景
- Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline in the biosynthesis of catecholamines. DBH is selectively expressed in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, and it serves as a specific protein marker for noradrenergic processes. The active form of DBH is a homotetramer, which is found in the lumen of synaptic vesicles of corresponding nerve cells, where it localizes to both the membrane and cytosol. DBH is induced by nerve growth factor and Insulin growth factor-1 and is regulated by intracellular second messengers protein kinase A, cyclic AMP, diacyl glycerol and Ca2+. Expression of DBH is transcriptionally mediated by Sp1, CREB and AP-1 proteins including c-Fos, c-Jun and JunD.
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UniProt
- P09172
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途径
- Carbohydrate Homeostasis
抗原
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