CARM1 抗体 (AA 200-400)
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Quick Overview for CARM1 抗体 (AA 200-400) (ABIN7872009)
抗原
See all CARM1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 200-400
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原理
- CARM1 Antibody / PRMT4
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the CARM1 antibody.
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亚型
- IgG2, kappa
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应用备注
- Optimal dilution of the CARM1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the CARM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CARM1 (Coactivator-Associated Arginine Methyltransferase 1 (CARM1))
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别名
- CARM1
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背景
- CARM1 (coactivator-associated arginine methyltransferase 1), also known as protein arginine N-methyltransferase 4 (PRMT4), is a 585 amino acid nuclear and cytoplasmic protein belonging to the protein arginine N-methyltransferase family. As a protein arginine N-methyltransferase, CARM1 is capable of catalyzing the transfer of methyl groups from S-adenosylmethionine to the guanidino group nitrogen atoms of arginine residues in certain proteins involved in mRNA stability, DNA packaging and transcriptional regulation. The methyltransferase activity of CARM1 has been found to be negatively regulated through phosphorylation at a conserved serine residue. CARM1 acts as a positive regulator for multiple transcription factors and functions as a secondary coactivator through its association with p160 coactivators. CARM1 exists as two alternatively spliced isoforms, and is encoded by a gene that maps to human chromosome 19p13.2.
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UniProt
- Q86X55
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of fat Cell Differentiation
抗原
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