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AMBP 抗体 (AA 200-353)

This 小鼠 单克隆 antibody specifically detects AMBP in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7871975
发货至: 中国
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Quick Overview for AMBP 抗体 (AA 200-353) (ABIN7871975)

抗原

See all AMBP 抗体
AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

适用

  • 95
  • 27
  • 22
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1

宿主

  • 81
  • 26
  • 6
小鼠

克隆类型

  • 76
  • 36
单克隆

标记

  • 59
  • 13
  • 10
  • 6
  • 3
  • 3
  • 3
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  • 3
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  • 2
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This AMBP antibody is un-conjugated

应用范围

  • 76
  • 49
  • 38
  • 12
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  • 9
  • 5
  • 5
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  • 3
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  • 2
  • 1
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  • 1
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

AMBP-4536
  • 抗原表位

    • 9
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 200-353

    原理

    Alpha 1 Microglobulin Antibody / AMBP / Bikunin

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant partial protein sequence (within amino acids 200-353) from the human protein was used as the immunogen for the Alpha 1 Microglobulin antibody.

    亚型

    IgG2, kappa
  • 应用备注

    Optimal dilution of the Alpha 1 Microglobulin antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the Alpha 1 Microglobulin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

    别名

    Alpha 1 Microglobulin

    背景

    The AMBP (Alpha-1-Microglobulin/Bikunin precursor) gene encodes a protein precursor, known as AMBP, that is cleaved to produce two distinct proteins, designated Alpha-1-Microglobulin and Bikunin. Alpha-1-Microglobulin, also known as protein HC, is a member of the lipocalin superfamily and is secreted mainly in plasma, urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity, Alpha-1-Microglobulin exhibits immunosuppressive properties, such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation, and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product, designated Bikunin and also known as inter-Alpha-trypsin inhibitor light chain, ITI-LC or urinary trypsin inhibitor, is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family, Bikunin prevents autodigestion by exocrine enzymes, such as trypsinogen and chymo-trypsinogen, and plays a role in the antiinflammatory/antiproteinase immune response. Unlike Alpha-1-Microglobulin, Bikunin is implicated in the pathogenesis of a number of renal diseases, such as urolithiasis.

    UniProt

    P02760
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