AMBP 抗体 (AA 200-353)
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Quick Overview for AMBP 抗体 (AA 200-353) (ABIN7871975)
抗原
See all AMBP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 200-353
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原理
- Alpha 1 Microglobulin Antibody / AMBP / Bikunin
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 200-353) from the human protein was used as the immunogen for the Alpha 1 Microglobulin antibody.
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亚型
- IgG2, kappa
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应用备注
- Optimal dilution of the Alpha 1 Microglobulin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Alpha 1 Microglobulin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))
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别名
- Alpha 1 Microglobulin
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背景
- The AMBP (Alpha-1-Microglobulin/Bikunin precursor) gene encodes a protein precursor, known as AMBP, that is cleaved to produce two distinct proteins, designated Alpha-1-Microglobulin and Bikunin. Alpha-1-Microglobulin, also known as protein HC, is a member of the lipocalin superfamily and is secreted mainly in plasma, urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity, Alpha-1-Microglobulin exhibits immunosuppressive properties, such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation, and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product, designated Bikunin and also known as inter-Alpha-trypsin inhibitor light chain, ITI-LC or urinary trypsin inhibitor, is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family, Bikunin prevents autodigestion by exocrine enzymes, such as trypsinogen and chymo-trypsinogen, and plays a role in the antiinflammatory/antiproteinase immune response. Unlike Alpha-1-Microglobulin, Bikunin is implicated in the pathogenesis of a number of renal diseases, such as urolithiasis.
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UniProt
- P02760
抗原
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