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PCBP2 抗体 (AA 197-276)

The 兔 多克隆 anti-PCBP2 antibody is suitable to detect PCBP2 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, ELISA, IHC (p) 和 FACS.
产品编号 ABIN7871742
发货至: 中国
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Quick Overview for PCBP2 抗体 (AA 197-276) (ABIN7871742)

抗原

See all PCBP2 抗体
PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This PCBP2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
  • 抗原表位

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    AA 197-276

    原理

    PCBP2 Antibody / Poly(rC)-binding protein 2 / hnRNP E2

    纯化方法

    Affinity purified

    免疫原

    A human recombinant partial protein (amino acids Q197-K276) was used as the immunogen for the PCBP2 antibody.

    亚型

    IgG
  • 应用备注

    Optimal dilution of the PCBP2 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    4 °C,-20 °C

    储存方法

    After reconstitution, the PCBP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
  • 抗原

    PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

    别名

    PCBP2

    背景

    Poly(rC)-binding protein 2, also called Heterogeneous nuclear ribonucleoprotein E2 (hnRNP E2), is a protein that in humans is encoded by the PCBP2 gene. The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

    UniProt

    Q15366
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