PCBP2 抗体 (AA 197-276)
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Quick Overview for PCBP2 抗体 (AA 197-276) (ABIN7871742)
抗原
See all PCBP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 197-276
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原理
- PCBP2 Antibody / Poly(rC)-binding protein 2 / hnRNP E2
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纯化方法
- Affinity purified
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免疫原
- A human recombinant partial protein (amino acids Q197-K276) was used as the immunogen for the PCBP2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the PCBP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PCBP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))
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别名
- PCBP2
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背景
- Poly(rC)-binding protein 2, also called Heterogeneous nuclear ribonucleoprotein E2 (hnRNP E2), is a protein that in humans is encoded by the PCBP2 gene. The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.
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UniProt
- Q15366
抗原
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