SUV420H2/KMT5C 抗体 (AA 195-220)
Our Local Distributor
北京 101111
Quick Overview for SUV420H2/KMT5C 抗体 (AA 195-220) (ABIN7871703)
抗原
See all SUV420H2/KMT5C (SUV420H2) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 195-220
-
原理
- KMT5C Antibody / SUV420H2
-
免疫原
- A portion of amino acids 195-220 from the human protein was used as the immunogen for the KMT5C antibody.
-
亚型
- Ig Fraction
-
-
anti-Suppressor of Variegation 4-20 Homolog 2 (SUV420H2) (AA 2-279) antibody
SUV420H2 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 4-20 Homolog 2 (SUV420H2) (AA 100-200) antibodyKO Validated SUV420H2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 4-20 Homolog 2 (SUV420H2) (AA 187-214) antibodySUV420H2 适用: 小鼠, 人 WB, FACS 宿主: 兔 Polyclonal RB19392 unconjugated
anti-Suppressor of Variegation 4-20 Homolog 2 (SUV420H2) (AA 235-345) antibodySUV420H2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 4-20 Homolog 2 (SUV420H2) (AA 60-90) antibodySUV420H2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB14359 unconjugated
anti-Suppressor of Variegation 4-20 Homolog 2 (SUV420H2) antibodySUV420H2 适用: 小鼠, 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- The stated application concentrations are suggested starting points. Titration of the KMT5C antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Aliquot the KMT5C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))
-
别名
- KMT5C
-
背景
- KMT5C, also called Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 and Suv4-20h2, belongs to a family of proteins called lysine methyltransferases, which are enzymes that play a key role in the modification of histone proteins. Histones are proteins that help package and organize DNA in the nucleus of a cell, and modifications to these proteins can have profound effects on gene expression. Studies have shown that KMT5C specifically targets histone H4 lysine 20 (H4K20) for methylation, which has been linked to the regulation of gene transcription and DNA replication. Dysregulation of this process has been implicated in various diseases, including cancer and developmental disorders. In cancer, aberrant expression of KMT5C has been observed in several tumor types, and its overexpression has been associated with poor prognosis. Mutations in the KMT5C gene have been linked to developmental disorders, such as intellectual disability and autism spectrum disorders. These findings highlight the importance of KMT5C in brain development and function, and provide new insights into the underlying mechanisms of these conditions.
-
UniProt
- Q86Y97
抗原
-
