SELPLG 抗体 (AA 18-420)
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Quick Overview for SELPLG 抗体 (AA 18-420) (ABIN7871418)
抗原
See all SELPLG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 18-420
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原理
- Psgl-1 Antibody / Selplg
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纯化方法
- Affinity purified
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免疫原
- Recombinant rat protein (amino acids L18-P420) was used as the immunogen for the Psgl-1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Psgl-1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Psgl-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SELPLG (Selectin P Ligand (SELPLG))
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别名
- Psgl-1
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背景
- Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene. It is mapped to 12q16. This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
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UniProt
- Q8K5B0
抗原
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