TMEM9 抗体 (AA 18-183)
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Quick Overview for TMEM9 抗体 (AA 18-183) (ABIN7871397)
抗原
See all TMEM9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 18-183
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原理
- TMEM9 Antibody / Transmembrane protein 9
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TMEM9 recombinant protein (Position: A18-S183) was used as the immunogen for the TMEM9 antibody.
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亚型
- IgG
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anti-Transmembrane Protein 9 (TMEM9) (AA 111-183) antibody
TMEM9 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 9 (TMEM9) antibodyTMEM9 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 9 (TMEM9) (C-Term) antibodyTMEM9 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 斑马鱼, 小鸡, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 9 (TMEM9) (C-Term) antibodyTMEM9 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 9 (TMEM9) (C-Term) antibodyTMEM9 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 斑马鱼, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TMEM9 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TMEM9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TMEM9 (Transmembrane Protein 9 (TMEM9))
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别名
- TMEM9
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背景
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TMEM9 antibody detects Transmembrane protein 9, encoded by the TMEM9 gene on chromosome 1q41. TMEM9 antibody is widely used in research on vesicle trafficking, lysosomal biology, and cancer. TMEM9 is a small lysosomal transmembrane protein that functions as a regulator of vesicle acidification and lysosomal activity. It contributes to autophagy, protein degradation, and receptor recycling, making it important for cell metabolism and signaling.
Structurally, TMEM9 is a ~21 kDa protein predicted to contain multiple transmembrane domains. It localizes to late endosomes and lysosomes, where it interacts with vacuolar H+-ATPases (V-ATPases) to promote acidification of the organelle lumen. This acidification is required for hydrolytic enzyme activity, autophagosome maturation, and lysosomal degradation. TMEM9 is conserved across vertebrates and is essential for maintaining lysosomal homeostasis.
Functionally, TMEM9 promotes lysosomal degradation and autophagy by enhancing V-ATPase assembly. It also regulates receptor recycling and endosomal trafficking. Dysregulation of TMEM9 disrupts lysosomal activity, leading to accumulation of undegraded proteins and impaired autophagy. Researchers use TMEM9 antibody to study vesicle trafficking, lysosomal acidification, and autophagy regulation.
Clinically, TMEM9 has been linked to cancer progression. Overexpression of TMEM9 has been reported in colorectal and liver cancers, where it promotes tumor growth by enhancing Wnt/beta-catenin signaling and metabolic adaptation. It may serve as a biomarker of aggressive tumor behavior and a potential therapeutic target. NSJ Bioreagents provides TMEM9 antibody for lysosomal, cancer, and metabolism studies.
Experimentally, TMEM9 antibody is applied in western blotting to detect the ~21 kDa protein, in immunofluorescence to study lysosomal localization, and in immunohistochemistry to assess tissue-specific expression. Co-immunoprecipitation with TMEM9 antibody helps identify interactions with V-ATPase components. -
UniProt
- Q9P0T7
抗原
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