Synaptojanin 2 抗体 (AA 18-1495)
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Quick Overview for Synaptojanin 2 抗体 (AA 18-1495) (ABIN7871393)
抗原
See all Synaptojanin 2 (SYNJ2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 18-1495
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原理
- SYNJ2 Antibody / Synaptojanin 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SYNJ2 recombinant protein (Position: D18-K1495) was used as the immunogen for the SYNJ2 antibody.
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亚型
- IgG
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anti-Synaptojanin 2 (SYNJ2) (AA 1396-1495) antibody
SYNJ2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2H8 unconjugated
anti-Synaptojanin 2 (SYNJ2) (AA 1-839) antibodySYNJ2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Synaptojanin 2 (SYNJ2) (AA 679-707) antibodySYNJ2 适用: 人 WB 宿主: 兔 Polyclonal RB41921 unconjugated
anti-Synaptojanin 2 (SYNJ2) (AA 1396-1495) antibodySYNJ2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Synaptojanin 2 (SYNJ2) (AA 1-839) antibodySYNJ2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Synaptojanin 2 (SYNJ2) (AA 71-120) antibodySYNJ2 适用: 人, 大鼠, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Synaptojanin 2 (SYNJ2) (AA 1446-1496) antibodySYNJ2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Synaptojanin 2 (SYNJ2) (AA 1275-1325) antibodySYNJ2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Synaptojanin 2 (SYNJ2) antibodySYNJ2 适用: 人 WB 宿主: 兔 Monoclonal 25GB1640 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the SYNJ2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SYNJ2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Synaptojanin 2 (SYNJ2)
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别名
- SYNJ2
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背景
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SYNJ2 antibody detects Synaptojanin-2, a phosphoinositide phosphatase that regulates endocytosis, membrane trafficking, and cytoskeletal remodeling. Encoded by the SYNJ2 gene on chromosome 6q25.3, this protein belongs to the inositol polyphosphate 5-phosphatase family and contains a Sac1-like domain, a 5-phosphatase catalytic domain, and a proline-rich region for binding endocytic adaptor proteins. By hydrolyzing phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), SYNJ2 controls membrane curvature, vesicle uncoating, and receptor recycling. It plays a pivotal role in clathrin-mediated endocytosis and growth factor signaling regulation.
SYNJ2 is expressed in many tissues, with particularly high levels in the brain, liver, and kidney. It localizes to endocytic vesicles, the plasma membrane, and cytoplasmic puncta associated with actin filaments. Through its phosphatase activity, SYNJ2 terminates phosphoinositide-dependent signaling, facilitating the disassembly of endocytic complexes. It interacts with endophilins, amphiphysin, and dynamin to coordinate vesicle fission and cargo retrieval. In addition, SYNJ2 participates in insulin signaling and receptor recycling in adipocytes and hepatocytes, linking membrane trafficking to metabolic regulation.
The SYNJ2 antibody is widely used in neuroscience, cell biology, and cancer research to study phosphoinositide metabolism and endocytosis. Western blot analysis typically identifies a 170 kilodalton band corresponding to full-length Synaptojanin-2, while immunofluorescence reveals punctate staining along endocytic vesicles and actin-rich regions. Dysregulated SYNJ2 expression has been associated with enhanced tumor cell migration and invasion, particularly in breast and prostate cancers, where it drives actin remodeling and lamellipodia formation through PI3K signaling modulation.
Functionally, SYNJ2 acts at the intersection of signaling and membrane dynamics, ensuring timely lipid turnover and vesicle recycling. It also contributes to synaptic vesicle endocytosis, influencing neuronal plasticity and receptor availability. The SYNJ2 antibody supports these studies by providing precise detection of Synaptojanin-2 across multiple tissue types. NSJ Bioreagents supplies this antibody validated for its applications, enabling researchers to investigate the molecular mechanisms of phosphoinositide metabolism and signal termination. -
UniProt
- O15056
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途径
- Inositol Metabolic Process
抗原
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