NTSR2 抗体 (AA 176-392)
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Quick Overview for NTSR2 抗体 (AA 176-392) (ABIN7871339)
抗原
See all NTSR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 176-392
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原理
- NTSR2 Antibody / Neurotensin receptor type 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived mouse NTSR2 recombinant protein (Position: Q176-E392) was used as the immunogen for the NTSR2 antibody.
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亚型
- IgG
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anti-Neurotensin Receptor 2 (NTSR2) (AA 377-392), (Intracellular) antibody
NTSR2 适用: 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 2 (NTSR2) (AA 359-410) antibodyNTSR2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 2 (NTSR2) (Internal Region) antibodyNTSR2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 2 (NTSR2) (C-Term) antibodyNTSR2 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 2 (NTSR2) (Extracellular Domain) antibodyNTSR2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurotensin Receptor 2 (NTSR2) (AA 151-200) antibodyNTSR2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NTSR2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NTSR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NTSR2 (Neurotensin Receptor 2 (NTSR2))
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别名
- NTSR2
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背景
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NTSR2 antibody detects Neurotensin receptor type 2, a G protein-coupled receptor (GPCR) that mediates the effects of the neuropeptide neurotensin on neuronal activity, pain modulation, and inflammation. The UniProt recommended name is Neurotensin receptor type 2 (NTSR2). This receptor couples to G proteins to trigger intracellular calcium mobilization and MAPK pathway activation in response to neurotensin binding.
Functionally, NTSR2 antibody identifies a 410-amino-acid seven-transmembrane receptor localized primarily in the central nervous system and peripheral tissues. NTSR2 regulates dopaminergic signaling, nociception, and gastrointestinal motility. It is distinct from NTSR1 in its lower affinity for neurotensin and its unique coupling to Gq and Gi proteins, leading to both excitatory and inhibitory cellular effects.
The NTSR2 gene is located on chromosome 2p25.1 and is highly expressed in the brainstem, hypothalamus, and spinal cord. Peripheral expression in immune cells and smooth muscle contributes to neuroimmune and cardiovascular regulation. NTSR2 activation influences neurotransmitter release, stress response, and vascular tone.
Pathologically, dysregulation of NTSR2 signaling has been associated with pain disorders, schizophrenia, addiction, and cancer progression. Its activation promotes cell migration and survival in certain tumors. Research using NTSR2 antibody supports studies in neuroscience, signal transduction, and receptor pharmacology.
NTSR2 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect GPCRs and neuropeptide receptors. NSJ Bioreagents provides NTSR2 antibody reagents optimized for neurobiology, pharmacology, and signal transduction research.
Structurally, Neurotensin receptor type 2 features seven transmembrane helices typical of GPCRs, an extracellular ligand-binding region, and an intracellular tail that interacts with G proteins and arrestins. This antibody enables investigation of NTSR2's regulatory role in neurotransmission and cellular signaling. -
UniProt
- P70310
抗原
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