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Vinculin 抗体 (AA 174-322)

The 小鼠 单克隆 anti-Vinculin antibody is suitable to detect Vinculin in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7871295
发货至: 中国
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Quick Overview for Vinculin 抗体 (AA 174-322) (ABIN7871295)

抗原

See all Vinculin (VCL) 抗体
Vinculin (VCL)

适用

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宿主

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小鼠

克隆类型

  • 96
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单克隆

标记

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This Vinculin antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

VCL-2573
  • 抗原表位

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    AA 174-322

    原理

    Vinculin Antibody

    纯化方法

    Protein G affinity chromatography

    免疫原

    A portion of amino acids 174-322 from the human protein was used as the immunogen for this Vinculin antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the Vinculin antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the Vinculin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    Vinculin (VCL)

    别名

    Vinculin

    背景

    Focal adhesions are identified as areas within the plasma membrane of tissue culture cells that adhere tightly to the underlying substrate. In vivo, these regions are involved in the adhesion of cells to the extracellular matrix. Paxillin and vinculin are cytoskeletal, focal adhesion proteins that are components of a protein complex which links the Actin network to the plasma membrane. Vinculin binding sites have been identified on other cytoskeletal proteins, including Talin and alpha-Actinin. In addition, vinculin, Talin and alpha-Actinin each contain Actin binding sites. Expression of vinculin and Talin have been shown to be affected by the level of Actin expression. Alpha-Actinin has been shown to link Actin to integrins in the plasma membrane through interactions with the vinculin and Talin complex or by a direct interaction with integrin.

    UniProt

    P18206

    途径

    Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
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