STRIP2 抗体 (AA 173-507)
The 兔 多克隆 anti-STRIP2 antibody is suitable to detect STRIP2 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, IHC, ELISA 和 FACS.
产品编号 ABIN7871274
发货至:
中国
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Quick Overview for STRIP2 抗体 (AA 173-507) (ABIN7871274)
抗原
See all STRIP2 抗体
STRIP2
(Striatin Interacting Protein 2 (STRIP2))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This STRIP2 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
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抗原表位
- AA 173-507
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原理
- STRIP2 Antibody / Striatin-interacting protein 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human FAM40B/STRIP2 recombinant protein (Position: H173-Q507) was used as the immunogen for the STRIP2 antibody.
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亚型
- IgG
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anti-Striatin Interacting Protein 2 (STRIP2) (AA 14-41), (N-Term) antibody
STRIP2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB24816 unconjugated
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应用备注
- Optimal dilution of the STRIP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STRIP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STRIP2 (Striatin Interacting Protein 2 (STRIP2))
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别名
- STRIP2
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背景
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STRIP2 antibody detects Striatin-interacting protein 2, a scaffolding protein that functions as a regulatory component of the STRIPAK complex (striatin-interacting phosphatase and kinase complex). STRIP2 integrates protein phosphatase 2A (PP2A) signaling with cytoskeletal organization, cell motility, and developmental signaling. The STRIP2 antibody is used to study PP2A-mediated signal transduction, cell morphology, and organ development.
STRIP2 is encoded by the STRIP2 gene located on human chromosome 7q34. The protein is approximately 92 kilodaltons and shares structural features with STRIP1, including coiled-coil regions that mediate interactions with striatins, kinases, and phosphatases. Through the STRIPAK complex, STRIP2 influences actin dynamics, cell polarity, and cell-cell junction formation.
The STRIP2 antibody identifies a 90-100 kilodalton protein by western blot. STRIP2 functions as a scaffold that couples kinases such as MST1/2 and MAP4Ks to PP2A, thereby controlling phosphorylation-dependent signaling cascades. This coordination regulates tissue growth, planar cell polarity, and morphogenesis.
Loss or mutation of STRIP2 disrupts cytoskeletal organization and leads to abnormal cell migration and tissue formation. In the nervous system, STRIP2 is important for axon outgrowth and synapse development. Studies have linked STRIP2 mutations to congenital myopathies and developmental disorders. In cancer, dysregulated STRIP2 expression has been observed in breast, lung, and prostate tumors, where it may promote invasive behavior.
STRIP2 serves as a crucial adaptor that integrates mechanical and chemical signaling at the cell cortex. Its interactions with the Hippo pathway components connect STRIPAK signaling to growth regulation and organ size control. NSJ Bioreagents provides a validated STRIP2 antibody optimized for its applications facilitating studies of phosphatase regulation, cytoskeletal architecture, and signal coordination. -
UniProt
- Q9ULQ0
抗原
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