DCK 抗体 (AA 171-200)
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Quick Overview for DCK 抗体 (AA 171-200) (ABIN7871260)
抗原
See all DCK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 171-200
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原理
- Deoxycytidine kinase Antibody / DCK
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纯化方法
- Purified
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免疫原
- A portion of amino acids 171-200 from the human protein was used as the immunogen for the Deoxycytidine kinase antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Deoxycytidine kinase antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Deoxycytidine kinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- DCK (Deoxycytidine Kinase (DCK))
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别名
- Deoxycytidine kinase
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背景
- Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.
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UniProt
- P27707
抗原
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