beta-TrCP (AA 17-52) 抗体
The 兔 多克隆 anti-beta-TrCP antibody (ABIN7871239) specifically detects beta-TrCP in IF, WB 和 IHC (p).
The antibody is reactive with 人 samples.
产品编号 ABIN7871239
发货至:
中国
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中国
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Quick Overview for beta-TrCP (AA 17-52) 抗体 (ABIN7871239)
抗原
beta-TrCP
适用
人
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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抗原表位
- AA 17-52
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原理
- Beta-TrCP Antibody / BTRC
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 17-52 from the human protein was used as the immunogen for the Beta-TrCP antibody.
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亚型
- Ig Fraction
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anti-beta-TrCP antibody
适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-beta-TrCP antibody适用: 人, 小鼠 IF, WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Beta-TrCP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Beta-TrCP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- beta-TrCP
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背景
- This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
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UniProt
- Q9Y297
抗原
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