PPM1F 抗体 (AA 17-454)
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Quick Overview for PPM1F 抗体 (AA 17-454) (ABIN7871232)
抗原
See all PPM1F 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 17-454
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原理
- PPM1F Antibody / Protein phosphatase 1F / POPX2
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids E17-S454) was used as the immunogen for the PPM1F antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the PPM1F antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PPM1F antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))
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别名
- PPM1F
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背景
- Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
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UniProt
- P49593
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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