BCCIP 抗体 (AA 167-300)
Our Local Distributor
北京 101111
Quick Overview for BCCIP 抗体 (AA 167-300) (ABIN7871194)
抗原
See all BCCIP 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 167-300
-
原理
- BCCIP Antibody / BRCA2 and CDKN1A-interacting protein
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human BCCIP recombinant protein (Position: K167-K300) was used as the immunogen for the BCCIP antibody.
-
亚型
- IgG
-
-
anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) (AA 1-314) antibody
BCCIP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) (C-Term) antibodyBCCIP 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) (AA 1-322) antibodyBCCIP 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) (AA 300-350) antibodyBCCIP 适用: 人 IHC, IF (p) 宿主: 兔 Polyclonal unconjugated
anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) (AA 1-314) antibodyBCCIP 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) (C-Term) antibodyBCCIP 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) antibodyBCCIP 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) (AA 210-314) antibodyBCCIP 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-BRCA2 and CDKN1A Interacting Protein (BCCIP) (C-Term) antibodyBCCIP 适用: 人 IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the BCCIP antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the BCCIP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))
-
别名
- BCCIP
-
背景
-
BCCIP antibody detects BRCA2 and CDKN1A-interacting protein, a nuclear protein involved in DNA repair, cell cycle regulation, and genome maintenance. Encoded by the BCCIP gene on chromosome 10q26.2, this protein interacts with BRCA2 and p21 (CDKN1A) to facilitate homologous recombination and checkpoint control. BCCIP functions as a cofactor in the BRCA2-RAD51 repair complex, promoting the repair of double-strand breaks and ensuring replication fork stability during DNA synthesis.
Structurally, BCCIP contains conserved coiled-coil domains and an acidic region that mediate protein-protein interactions with DNA repair and replication factors. It is expressed in proliferating cells and localizes primarily to the nucleus, particularly at sites of DNA damage. Through its association with p21, BCCIP also influences CDK activity and contributes to G1/S and G2/M checkpoint control.
The BCCIP antibody is widely used in DNA repair, oncology, and cell cycle research to study BRCA2-associated homologous recombination and genomic integrity. Western blot analysis identifies a 36 kilodalton band corresponding to BCCIP, while immunofluorescence shows nuclear punctate staining consistent with DNA damage foci. This antibody enables detection of repair complex dynamics and checkpoint activation in mammalian cells.
Dysregulation of BCCIP expression impairs DNA repair fidelity, leading to chromosomal instability, replication stress, and increased tumor susceptibility. Reduced BCCIP levels have been observed in glioblastoma and colorectal cancer, supporting its role as a tumor suppressor. The BCCIP antibody provides a reliable reagent for exploring DNA damage response and tumorigenic mechanisms. NSJ Bioreagents validates this antibody for western blotting, immunohistochemistry, and immunofluorescence, ensuring consistent results for genomic stability studies. -
UniProt
- Q9P287
抗原
-
