TDO2 抗体 (AA 16-406)
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Quick Overview for TDO2 抗体 (AA 16-406) (ABIN7871075)
抗原
See all TDO2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 16-406
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原理
- TDO2 Antibody / Tryptophan 2,3-dioxygenase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TDO2 recombinant protein (Position: K16-D406) was used as the immunogen for the TDO2 antibody.
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亚型
- IgG
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anti-Tryptophan 2,3-Dioxygenase (TDO2) antibody
TDO2 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2A4 unconjugated
anti-Tryptophan 2,3-Dioxygenase (TDO2) (N-Term) antibodyTDO2 适用: 人, 犬, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tryptophan 2,3-Dioxygenase (TDO2) (AA 1-406) antibodyTDO2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tryptophan 2,3-Dioxygenase (TDO2) (AA 1-406) antibodyTDO2 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Tryptophan 2,3-Dioxygenase (TDO2) (N-Term) antibodyTDO2 适用: 人, 犬, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tryptophan 2,3-Dioxygenase (TDO2) (N-Term) antibodyTDO2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Tryptophan 2,3-Dioxygenase (TDO2) (AA 1-406) antibodyTDO2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tryptophan 2,3-Dioxygenase (TDO2) (AA 307-405) antibodyTDO2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Tryptophan 2,3-Dioxygenase (TDO2) (AA 307-405) antibodyTDO2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Tryptophan 2,3-Dioxygenase (TDO2) (AA 137-406) antibodyTDO2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TDO2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TDO2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TDO2 (Tryptophan 2,3-Dioxygenase (TDO2))
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别名
- TDO2
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背景
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TDO2 antibody detects tryptophan 2,3-dioxygenase, a heme-dependent enzyme that catalyzes the first step of the kynurenine pathway, converting L-tryptophan to N-formylkynurenine. The UniProt recommended name is Tryptophan 2,3-dioxygenase (TDO2). This enzyme regulates systemic tryptophan levels and influences serotonin biosynthesis, immune tolerance, and NAD+ metabolism.
Functionally, TDO2 antibody identifies a homotetrameric enzyme that incorporates molecular oxygen into the indole ring of tryptophan. The enzyme is predominantly expressed in liver but is inducible in many tumor types. TDO2 activity shapes the immune microenvironment by depleting tryptophan and generating immunosuppressive kynurenine metabolites. This mechanism contributes to tumor immune evasion and cancer progression.
The TDO2 gene is located on chromosome 4q32.1 and encodes a 406-amino-acid protein with a conserved heme-binding pocket. Its expression is transcriptionally induced by glucocorticoids, stress, and pro-inflammatory cytokines. Elevated TDO2 levels have been reported in hepatocellular carcinoma, glioblastoma, and melanoma, positioning it as a therapeutic target in oncology. TDO2 also regulates neuroactive tryptophan metabolites implicated in mood disorders and neurodegeneration.
Pathologically, upregulation of TDO2 disturbs immune cell proliferation and antigen presentation through depletion of tryptophan and accumulation of kynurenine. Inhibiting TDO2 restores T-cell activity and is an emerging immunotherapeutic strategy complementary to checkpoint blockade. In metabolic studies, altered TDO2 activity links to hepatic inflammation and altered redox homeostasis.
TDO2 antibody is widely applied in cancer immunology, metabolism, and neurobiology research. It is suitable for immunoblotting, immunohistochemistry, and enzyme assays detecting TDO2 expression or localization. NSJ Bioreagents supplies high-quality TDO2 antibody reagents validated for use in relevant metabolic and immunological assays.
Structurally, tryptophan 2,3-dioxygenase possesses a catalytic heme group coordinated by a proximal histidine. Substrate binding induces conformational changes that enhance dioxygen activation. This antibody supports biochemical and translational studies targeting TDO2 for metabolic modulation and immunotherapy development. -
UniProt
- P48775
抗原
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