C1orf103 抗体 (AA 157-528)
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Quick Overview for C1orf103 抗体 (AA 157-528) (ABIN7871022)
抗原
See all C1orf103 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 157-528
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原理
- LRIF1 Antibody / Ligand-dependent nuclear receptor-interacting factor 1 / RIF-1 / HBiX1 / C1orf103
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human LRIF1 recombinant protein (Position: Q157-D528) was used as the immunogen for the LRIF1 antibody.
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亚型
- IgG
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anti-Chromosome 1 Open Reading Frame 103 (C1orf103) (AA 1-436) antibody
C1orf103 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 103 (C1orf103) (AA 521-620) antibodyC1orf103 适用: 大鼠 IF (p), ELISA, IF (cc), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 103 (C1orf103) antibodyC1orf103 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 103 (C1orf103) (N-Term) antibodyC1orf103 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 103 (C1orf103) (AA 35-84) antibodyC1orf103 适用: 人, 小鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 103 (C1orf103) (AA 683-732) antibodyC1orf103 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the LRIF1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the LRIF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- C1orf103 (Chromosome 1 Open Reading Frame 103 (C1orf103))
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别名
- LRIF1
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背景
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LRIF1 antibody detects Ligand-dependent nuclear receptor-interacting factor 1, a chromatin-associated protein that modulates gene expression through interaction with retinoblastoma protein (RB1) and nuclear receptors. The UniProt recommended name is Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1). Also known as RIF-1 or HBiX1, this protein functions in transcriptional repression and chromatin organization at heterochromatic regions.
Functionally, LRIF1 antibody identifies a 568-amino-acid nuclear protein that forms complexes with RB1 and heterochromatin protein 1 (HP1). LRIF1 recruits repressor complexes to chromatin and stabilizes transcriptionally silent regions, contributing to epigenetic control of gene activity. It also enhances ligand-dependent transcriptional regulation by nuclear receptors, integrating hormonal signaling with chromatin structure.
The LRIF1 gene is located on chromosome 1p36.11 and is ubiquitously expressed in proliferating and differentiated cells. LRIF1 plays key roles in cell cycle regulation, transcriptional silencing, and heterochromatin maintenance, particularly in gene-rich nuclear domains where it supports long-term epigenetic repression.
Pathologically, altered LRIF1 expression or mutation has been implicated in cancer progression and neurodevelopmental disorders through dysregulated chromatin remodeling. Its interaction with RB1 links LRIF1 to tumor-suppressive pathways that control proliferation and differentiation. Research using LRIF1 antibody supports studies in epigenetics, nuclear receptor signaling, and transcriptional repression.
LRIF1 antibody is validated for western blotting, immunoprecipitation, and immunofluorescence to detect chromatin-associated factors and nuclear corepressors. NSJ Bioreagents provides LRIF1 antibody reagents optimized for research in transcriptional regulation, chromatin biology, and epigenetic control.
Structurally, Ligand-dependent nuclear receptor-interacting factor 1 contains coiled-coil and leucine-rich motifs mediating protein-protein interactions with RB1 and HP1. This antibody aids exploration of LRIF1's role in heterochromatin stability and nuclear receptor signaling. -
UniProt
- Q5T3J3
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途径
- Nuclear Hormone Receptor Binding
抗原
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