C11orf35 抗体 (AA 155-634)
The 兔 多克隆 anti-C11orf35 antibody (ABIN7871011) specifically detects C11orf35 in ELISA, FACS 和 WB.
The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7871011
发货至:
中国
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中国
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Quick Overview for C11orf35 抗体 (AA 155-634) (ABIN7871011)
抗原
C11orf35
(Chromosome 11 Open Reading Frame 35 (C11orf35))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This C11orf35 antibody is un-conjugated
应用范围
ELISA, Flow Cytometry (FACS), Western Blotting (WB)
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抗原表位
- AA 155-634
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原理
- LMNTD2 Antibody / Lamin tail domain-containing protein 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human LMNTD2 recombinant protein (Position: E155-A634) was used as the immunogen for the LMNTD2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the LMNTD2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the LMNTD2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- C11orf35 (Chromosome 11 Open Reading Frame 35 (C11orf35))
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别名
- LMNTD2
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背景
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The LMNTD2 antibody targets Lamina-associated polypeptide 2-like protein, encoded by the LMNTD2 gene. This protein belongs to a family of nuclear envelope-associated proteins that contribute to maintaining nuclear architecture and regulating gene expression. Lamina-associated polypeptide 2-like protein contains conserved coiled-coil and spectrin-repeat regions that enable interactions with nuclear envelope components and cytoskeletal elements. The LMNTD2 antibody supports detailed study of nuclear organization, mechanotransduction, and gene regulation processes mediated by the nuclear lamina.
Lamina-associated proteins link chromatin to the inner nuclear membrane and regulate nuclear stiffness, positioning, and transcriptional activity. Although the precise function of Lamina-associated polypeptide 2-like protein remains under characterization, studies suggest it participates in nuclear envelope remodeling during cell division and differentiation. The LMNTD2 antibody enables researchers to localize the protein in interphase nuclei and monitor its redistribution during mitosis, offering insights into how nuclear membrane components influence cell cycle progression.
LMNTD2 expression has been detected across multiple tissues, including brain, heart, and skeletal muscle, suggesting a structural role in maintaining nuclear integrity in mechanically active cells. The protein may interact with lamins (LMNA, LMNB1) and emerin to stabilize the nuclear lamina. Disruption of such interactions can alter chromatin organization and lead to nuclear shape abnormalities often associated with laminopathies and premature aging syndromes. The LMNTD2 antibody allows investigation of these interactions and potential implications in human disease.
Beyond structural maintenance, Lamina-associated polypeptide 2-like protein may influence transcriptional regulation by tethering specific genomic regions to the nuclear periphery. This positioning can repress or activate gene expression depending on chromatin context. The LMNTD2 antibody is valuable for examining spatial genome organization, nuclear compartmentalization, and mechanosensitive gene regulation, topics of growing interest in cell biology and epigenetics.
The LMNTD2 antibody is effective in immunofluorescence, western blotting, and immunohistochemistry, providing a clear nuclear envelope signal in cell-based assays. Its use helps identify structural changes in disease models, evaluate protein-protein interactions, and assess the impact of mechanical stress on nuclear organization. NSJ Bioreagents provides the LMNTD2 antibody as a reliable and validated reagent for studies of nuclear envelope biology. Through consistent detection and quantification, this antibody supports research on how Lamina-associated polypeptide 2-like protein contributes to nuclear integrity, gene expression, and cellular mechanotransduction. -
UniProt
- Q8IXW0
抗原
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