GLMN 抗体 (AA 153-574)
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Quick Overview for GLMN 抗体 (AA 153-574) (ABIN7870988)
抗原
See all GLMN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 153-574
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原理
- GLMN Antibody / Glomulin
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GLMN recombinant protein (Position: Q153-R574) was used as the immunogen for the GLMN antibody.
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亚型
- IgG
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anti-Glomulin, FKBP Associated Protein (GLMN) (AA 1-594) antibody
GLMN 适用: 人 WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 1C12 unconjugated
anti-Glomulin, FKBP Associated Protein (GLMN) (AA 1-594) antibodyGLMN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Glomulin, FKBP Associated Protein (GLMN) antibodyGLMN 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glomulin, FKBP Associated Protein (GLMN) (AA 498-525), (C-Term) antibodyGLMN 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB31988 unconjugated
anti-Glomulin, FKBP Associated Protein (GLMN) (AA 294-549) antibodyGLMN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glomulin, FKBP Associated Protein (GLMN) (AA 1-594) antibodyGLMN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Glomulin, FKBP Associated Protein (GLMN) (AA 505-533), (C-Term) antibodyGLMN 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Glomulin, FKBP Associated Protein (GLMN) (AA 151-250) antibodyGLMN 适用: 人 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glomulin, FKBP Associated Protein (GLMN) (N-Term) antibodyGLMN 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GLMN antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GLMN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GLMN (Glomulin, FKBP Associated Protein (GLMN))
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别名
- GLMN
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背景
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GLMN antibody detects Glomulin, a cytoplasmic protein involved in ubiquitin-mediated protein degradation, vascular development, and smooth muscle cell regulation. Encoded by the GLMN gene on chromosome 1p22.1, this protein functions as an essential component of the E3 ubiquitin ligase complex that controls the turnover of signaling proteins in vascular and developmental pathways. GLMN acts as a suppressor of angiogenic signaling and maintains vascular integrity by promoting proper endothelial and smooth muscle interactions.
Glomulin interacts with Cullin-RING ligases and the SKP1-CUL1-F-box (SCF) complex, regulating substrate ubiquitination and degradation. By controlling ubiquitin homeostasis, it helps maintain cellular proteostasis and vessel wall stability. GLMN localizes to the cytoplasm and perinuclear regions, consistent with its role in ubiquitin regulation and protein quality control.
The GLMN antibody is used in vascular biology, developmental, and protein degradation research to investigate ubiquitination processes, angiogenesis, and smooth muscle differentiation. Western blot analysis identifies a 68 kilodalton band corresponding to Glomulin, while immunofluorescence shows cytoplasmic and perinuclear localization in endothelial and fibroblast cells. This antibody supports the study of vascular signaling and ubiquitin regulation mechanisms.
Mutations in GLMN cause glomuvenous malformations (glomangiomas), benign vascular lesions characterized by aberrant smooth muscle proliferation due to disrupted ubiquitin signaling. GLMN also participates in cell cycle regulation and differentiation, linking protein degradation to tissue morphogenesis. The GLMN antibody provides a robust reagent for studying ubiquitin-related vascular disorders and developmental signaling. NSJ Bioreagents validates this antibody for its applications, ensuring high specificity and reproducibility for vascular and ubiquitin pathway research. -
UniProt
- Q92990
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途径
- Tube Formation
抗原
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