PCBP1 抗体 (AA 152-268)
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Quick Overview for PCBP1 抗体 (AA 152-268) (ABIN7870977)
抗原
See all PCBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 152-268
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原理
- PCBP1 Antibody
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纯化方法
- Affinity purified
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免疫原
- A human recombinant partial protein (amino acids P152-K268) was used as the immunogen for the PCBP1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the PCBP1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PCBP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
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别名
- PCBP1
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背景
- Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene. This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
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UniProt
- Q15365
抗原
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