WT1 抗体 (AA 150-350)
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北京 101111
Quick Overview for WT1 抗体 (AA 150-350) (ABIN7870961)
抗原
See all WT1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 150-350
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原理
- Wilms Tumor 1 Antibody
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein (within amino acids 150-350) from the human protein was used as the immunogen for the Wilms Tumor 1 antibody.
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亚型
- IgG1, kappa
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anti-Wilms Tumor 1 (WT1) (AA 1-302) antibody
WT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Wilms Tumor 1 (WT1) (AA 1-181) antibodyWT1 适用: 人, 猴 IHC, WB, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 7F9E8 unconjugated
anti-Wilms Tumor 1 (WT1) antibodyWT1 适用: 人, 大鼠, 小鼠 IHC, WB 宿主: 小鼠 Monoclonal rWT1-857 unconjugated Recombinant Antibody
anti-Wilms Tumor 1 (WT1) (AA 1-181) antibodyWT1 适用: 人, 猴 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 7F9G7H2 unconjugated
anti-Wilms Tumor 1 (WT1) (AA 346-375) antibodyWT1 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB18841 unconjugated
anti-Wilms Tumor 1 (WT1) (C-Term) antibodyWT1 适用: 人, 大鼠, 小鼠, 兔, 犬, 猴, Bat, 小鸡, 非洲爪蟾 IHC, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Wilms Tumor 1 (WT1) (AA 1-181) antibodyWT1 适用: 人, 大鼠, 小鼠 IHC 宿主: 小鼠 Monoclonal 6F-H2 unconjugated
anti-Wilms Tumor 1 (WT1) (AA 1-302) antibodyWT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Wilms Tumor 1 (WT1) (AA 314-479) antibodyWT1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 5G11A5 unconjugated
anti-Wilms Tumor 1 (WT1) (Middle Region) antibodyWT1 适用: 人, 大鼠, 小鼠, Cow, 兔, 犬, Pig, 斑马鱼, 马 IHC, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Wilms Tumor 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Wilms Tumor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- WT1 (Wilms Tumor 1 (WT1))
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别名
- Wilms Tumor 1
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背景
- The WT1 gene located at chromosome 11p13 codes for a transcription factor, a DNA-binding nucleoprotein, that plays a role primarily in the development of genitourinary organs. There are at least eight isoforms ranging between 52 and 62 kDa produced by a combination of alternative splicing and RNA editing. WT1 is synthesized and reside in the cytoplasm in an inactive form. When activated through phosphorylation it is translocated to the nucleus. WT1 influences cell proliferation by suppressing bcl-2 and regulating cadherin and p53. In normal epithelia, nuclear WT1 expression is largely restricted to ovary (surface epithelium and inclusion cysts) and fallopian tube, while WT1 is not found in endometrial or cervical epithelium. As regards nonepithelial cells, nuclear WT1 is found in mesothelium and some sub mesothelial stromal cells, stromal cells of the female genital tract, testicular non-germinal cells, and kidney (podocytes). In tumor tissues, WT1 is detected in tumor cells of Wilms Tumor (also known as nephroblastoma) and mesothelioma. Additionally, WT1 expression has been found in ovarian serous carcinomas and some breast carcinomas.WT1 is particularly used for distinguishing malignant mesothelioma and ovarian serous carcinoma from nonserous carcinomas. As for malignant mesothelioma, calretinin and WT1 are superior to cytokeratin 5/6, N-cadherin and thrombomodulin. WT1 is also applicable for the differential diagnostic of small cell childhood tumors.
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UniProt
- P19544
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途径
- Tube Formation
抗原
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