TBR1 抗体 (AA 15-682)
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Quick Overview for TBR1 抗体 (AA 15-682) (ABIN7870804)
抗原
See all TBR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 15-682
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原理
- TBR1 Antibody / T-box brain protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TBR1 recombinant protein (Position: K15-S682) was used as the immunogen for the TBR1 antibody.
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亚型
- IgG
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anti-T-Box Brain Gene 1 (TBR1) (AA 1-108) antibody
TBR1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F6 unconjugated
anti-T-Box Brain Gene 1 (TBR1) (AA 1-108) antibodyTBR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-T-Box Brain Gene 1 (TBR1) (AA 51-100) antibodyTBR1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, Pig, 豚鼠, 马, 猴, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-T-Box Brain Gene 1 (TBR1) antibodyTBR1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-T-Box Brain Gene 1 (TBR1) (AA 128-145) antibodyTBR1 适用: 小鼠, 大鼠 IHC, ICC, IHC (p) 宿主: 豚鼠 Polyclonal unconjugated
anti-T-Box Brain Gene 1 (TBR1) (N-Term) antibodyTBR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-T-Box Brain Gene 1 (TBR1) (AA 575-624) antibodyTBR1 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-T-Box Brain Gene 1 (TBR1) (AA 52-80), (N-Term) antibodyTBR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB36695 unconjugated
anti-T-Box Brain Gene 1 (TBR1) (N-Term) antibodyTBR1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-T-Box Brain Gene 1 (TBR1) (AA 52-80) antibodyTBR1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TBR1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TBR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TBR1 (T-Box Brain Gene 1 (TBR1))
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别名
- TBR1
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背景
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TBR1 antibody detects T-box brain protein 1, a neuron-specific transcription factor that regulates cortical development and neuronal differentiation. The UniProt recommended name is T-box brain protein 1 (TBR1). This DNA-binding transcription factor belongs to the T-box family and is essential for neocortical layer specification, axonal guidance, and synaptic connectivity.
Functionally, TBR1 antibody identifies a 682-amino-acid nuclear protein that binds T-box DNA consensus sequences to regulate the expression of genes involved in neuronal subtype identity and projection targeting. TBR1 interacts with transcriptional co-regulators such as CASK, FOXP2, and SOX5, forming complexes that guide early cortical neuron differentiation and maturation.
The TBR1 gene is located on chromosome 2q24.2 and is expressed predominantly in postmitotic glutamatergic neurons of the developing and adult cerebral cortex. It functions as a key determinant of cortical layer VI identity and regulates axonal projections to subcortical targets. TBR1 is a downstream effector of the transcription factor PAX6, linking progenitor differentiation to neuronal specialization.
Pathologically, TBR1 mutations have been associated with autism spectrum disorders, intellectual disability, and cortical malformations. Its dysregulation disrupts neuronal migration, synapse formation, and interhemispheric connectivity. Research using TBR1 antibody provides insights into neurodevelopmental biology, transcriptional regulation, and disease mechanisms involving cortical circuitry.
TBR1 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry to label developing cortical neurons and nuclear transcription factors. NSJ Bioreagents offers validated TBR1 antibody reagents optimized for studies in neurogenesis, brain development, and transcriptional control.
Structurally, T-box brain protein 1 contains a central T-box DNA-binding domain that mediates sequence-specific gene regulation. It acts as both an activator and repressor depending on its interacting partners. This antibody enables researchers to explore TBR1's roles in cortical specification and neural differentiation. -
UniProt
- Q16650
抗原
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