Merlin 抗体 (AA 15-565)
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Quick Overview for Merlin 抗体 (AA 15-565) (ABIN7870799)
抗原
See all Merlin (NF2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 15-565
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原理
- Merlin Antibody / NF2
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纯化方法
- Affinity purified
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免疫原
- A human recombinant protein (amino acids K15-N565) was used as the immunogen for the Merlin antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Merlin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Merlin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Merlin (NF2) (Neurofibromin 2 (NF2))
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别名
- Merlin
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背景
- Human merlin is coded by the gene NF2 on chromosome 22. It is mapped to 22q12.2. This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
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UniProt
- P35240
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途径
- Cell-Cell Junction Organization
抗原
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