PATZ1 抗体 (AA 145-680)
Our Local Distributor
北京 101111
Quick Overview for PATZ1 抗体 (AA 145-680) (ABIN7870729)
抗原
See all PATZ1 (ZNF278) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 145-680
-
原理
- PATZ1 Antibody / POZ-, AT hook-, and zinc finger-containing protein 1
-
纯化方法
- Antigen affinity purified
-
免疫原
- An E.coli-derived human recombinant protein (amino acids M145-Q680) was used as the immunogen for the PATZ1 antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the PATZ1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the PATZ1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))
-
别名
- PATZ1
-
背景
- POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene. The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
-
UniProt
- Q9HBE1
抗原
-