WDR26 抗体 (AA 142-583)
The 兔 多克隆 anti-WDR26 antibody (ABIN7870693) specifically detects WDR26 in WB, FACS, ELISA, ICC 和 IF.
The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7870693
发货至:
中国
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Quick Overview for WDR26 抗体 (AA 142-583) (ABIN7870693)
抗原
See all WDR26 抗体
WDR26
(WD Repeat Domain 26 (WDR26))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This WDR26 antibody is un-conjugated
应用范围
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
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抗原表位
- AA 142-583
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原理
- WDR26 Antibody / WD repeat domain-containing protein 26
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human WDR26 recombinant protein (Position: Q142-E583) was used as the immunogen for the WDR26 antibody.
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亚型
- IgG
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anti-WD Repeat Domain 26 (WDR26) (AA 101-200) antibody
WDR26 适用: 人, 小鼠, 大鼠 WB, FACS, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-WD Repeat Domain 26 (WDR26) (AA 600-650) antibodyWDR26 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the WDR26 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the WDR26 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- WDR26 (WD Repeat Domain 26 (WDR26))
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别名
- WDR26
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背景
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WDR26 antibody detects WD repeat domain-containing protein 26, a multifunctional adaptor protein that participates in G protein-coupled receptor (GPCR) signaling, cytoskeletal regulation, and cell proliferation. Encoded by the WDR26 gene on chromosome 1q42.11, this protein contains several WD40 repeats that form a beta-propeller structure facilitating protein-protein interactions. WDR26 functions as a scaffold that coordinates signal transduction and cytoskeletal rearrangements downstream of heterotrimeric G proteins and growth factor receptors.
WDR26 localizes to both the cytoplasm and plasma membrane, where it binds Gbetagamma subunits and regulates downstream effectors such as PI3K, AKT, and ERK. By modulating these pathways, it controls cell migration, survival, and proliferation. Additionally, WDR26 plays roles in vesicle trafficking, stress response, and cell morphology through interactions with actin-associated proteins.
The WDR26 antibody is used in signaling, oncology, and molecular biology research to investigate scaffolding functions and GPCR-mediated pathways. Western blot analysis identifies a 65 kilodalton band corresponding to WDR26, while immunofluorescence shows cytoplasmic and membrane-associated staining. This antibody supports the study of protein complexes that regulate cellular communication and structure.
Aberrant expression of WDR26 has been linked to cancer progression and inflammatory signaling. Elevated WDR26 enhances AKT phosphorylation and cell survival, contributing to chemoresistance and metastasis, while loss of expression disrupts signaling coordination. The WDR26 antibody provides a valuable tool for exploring these mechanisms in disease and cellular physiology. NSJ Bioreagents validates this antibody for its applications, ensuring reliable performance in GPCR and signal transduction studies. -
UniProt
- Q9H7D7
抗原
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