Queuine tRNA-Ribosyltransferase Accessory Subunit 2 (QTRT2) (AA 142-386) 抗体
The 兔 多克隆 anti-Queuine tRNA-Ribosyltransferase Accessory Subunit 2 antibody (ABIN7870690) specifically detects Queuine tRNA-Ribosyltransferase Accessory Subunit 2 in WB 和 ELISA.
The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7870690
发货至:
中国
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Quick Overview for Queuine tRNA-Ribosyltransferase Accessory Subunit 2 (QTRT2) (AA 142-386) 抗体 (ABIN7870690)
抗原
Queuine tRNA-Ribosyltransferase Accessory Subunit 2 (QTRT2)
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB), ELISA
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抗原表位
- AA 142-386
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原理
- QTRT2 Antibody / Queuine tRNA-ribosyltransferase subunit 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human QTRT2 recombinant protein (Position: Q142-H386) was used as the immunogen for the QTRT2 antibody.
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亚型
- IgG
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anti-Queuine tRNA-Ribosyltransferase Accessory Subunit 2 (QTRT2) (AA 142-386) antibody
QTRT2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the QTRT2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the QTRT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Queuine tRNA-Ribosyltransferase Accessory Subunit 2 (QTRT2)
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别名
- QTRT2
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背景
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QTRT2 antibody detects Queuine tRNA-ribosyltransferase subunit 2, encoded by the QTRT2 gene on chromosome 6p25.1. QTRT2 antibody is widely used in RNA modification, translation, and metabolism research. QTRT2 partners with QTRT1 to form the heterodimeric tRNA-guanine transglycosylase complex that catalyzes incorporation of queuine into the anticodon wobble position of tRNAs. This modification enhances translation accuracy and efficiency.
Structurally, QTRT2 is a ~47 kDa protein that shares homology with QTRT1 but lacks catalytic residues. Instead, QTRT2 functions as a structural subunit that stabilizes the heterodimer and facilitates substrate recognition. QTRT2 localizes to the cytoplasm where tRNA modification occurs. It is conserved across eukaryotes, reflecting its fundamental role in translation regulation.
Functionally, QTRT2 supports tRNA modification that improves translational fidelity and codon-anticodon interactions. Queuine modification affects protein synthesis rates, cellular stress responses, and adaptation to nutrient availability. Researchers use QTRT2 antibody to investigate RNA modifications, translation quality control, and metabolic regulation.
Clinically, defects in queuine modification have been associated with cancer, neurodevelopmental disorders, and infection. Altered expression of QTRT2 has been reported in some tumors, suggesting a role in metabolic reprogramming and growth. Because RNA modifications are emerging therapeutic targets, QTRT2 is under active investigation. NSJ Bioreagents provides QTRT2 antibody to support RNA biology and translational control research.
Experimentally, QTRT2 antibody is applied in western blotting to detect the ~47 kDa protein, in immunofluorescence microscopy to study cytoplasmic localization, and in immunoprecipitation to analyze QTRT1-QTRT2 complexes. Functional assays combining QTRT2 antibody with RNA analysis confirm its role in tRNA modification. -
UniProt
- Q9H974
抗原
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