IPO7 抗体 (AA 142-169)
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Quick Overview for IPO7 抗体 (AA 142-169) (ABIN7870679)
抗原
See all IPO7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 142-169
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原理
- IPO7 Antibody / Importin 7
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 142-169 from the human protein was used as the immunogen for the IPO7 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the IPO7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the IPO7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- IPO7 (Importin 7 (IPO7))
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别名
- IPO7
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背景
- The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.
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UniProt
- O95373
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途径
- Protein targeting to Nucleus
抗原
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