NAGK 抗体 (AA 14-261)
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Quick Overview for NAGK 抗体 (AA 14-261) (ABIN7870623)
抗原
See all NAGK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 14-261
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原理
- NAGK Antibody / N-acetyl-D-glucosamine kinase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NAGK recombinant protein (Position: R14-K261) was used as the immunogen for the NAGK antibody.
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亚型
- IgG
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anti-N-Acetylglucosamine Kinase (NAGK) antibody
KD Validated NAGK 适用: 人 WB, FACS, IF (p) 宿主: 小鼠 Monoclonal 24GB14215 unconjugated
anti-N-Acetylglucosamine Kinase (NAGK) (AA 1-344) antibodyNAGK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H8 unconjugated
anti-N-Acetylglucosamine Kinase (NAGK) antibodyNAGK 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-N-Acetylglucosamine Kinase (NAGK) (AA 1-69) antibodyNAGK 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-N-Acetylglucosamine Kinase (NAGK) (AA 1-344) antibodyNAGK 适用: 人 WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal AT4D12 unconjugated
anti-N-Acetylglucosamine Kinase (NAGK) antibodyKD Validated NAGK 适用: 人 WB 宿主: 小鼠 Monoclonal 25GB6035 unconjugated
anti-N-Acetylglucosamine Kinase (NAGK) (AA 300-330), (C-Term) antibodyNAGK 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB5452 unconjugated
anti-N-Acetylglucosamine Kinase (NAGK) (AA 201-300) antibodyNAGK 适用: 小鼠 WB, ELISA, IF (p), IF (cc), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-N-Acetylglucosamine Kinase (NAGK) (AA 2-344) antibodyNAGK 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-N-Acetylglucosamine Kinase (NAGK) (AA 50-210) antibodyNAGK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NAGK antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NAGK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NAGK (N-Acetylglucosamine Kinase (NAGK))
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别名
- NAGK
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背景
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NAGK antibody detects N-acetyl-D-glucosamine kinase, encoded by the NAGK gene on chromosome 2p13.3. NAGK antibody is widely used in metabolism, glycosylation, and signaling research. NAGK is an enzyme of the hexosamine biosynthetic pathway that phosphorylates N-acetylglucosamine (GlcNAc) to GlcNAc-6-phosphate. This reaction contributes to the salvage pathway of UDP-GlcNAc biosynthesis, supporting protein glycosylation, glycosaminoglycan synthesis, and O-GlcNAc signaling.
Structurally, NAGK is a ~37 kDa cytoplasmic protein belonging to the sugar kinase family. It forms homodimers and contains an ATP-binding site and catalytic residues conserved among carbohydrate kinases. NAGK is broadly expressed across tissues, reflecting its role in basic carbohydrate metabolism.
Functionally, NAGK channels free GlcNAc into UDP-GlcNAc production, which is required for N- and O-linked glycosylation of proteins and for biosynthesis of glycolipids and proteoglycans. It plays a critical role in cell growth, signaling, and metabolic adaptation. Researchers use NAGK antibody to study carbohydrate metabolism, glycosylation pathways, and metabolic regulation.
Clinically, altered NAGK activity is associated with metabolic diseases and cancer. Increased NAGK expression has been reported in certain tumors, where it supports growth by boosting glycosylation and nutrient sensing pathways. Because protein glycosylation is a therapeutic target, NAGK is under investigation as a biomarker and regulator of cancer metabolism. NSJ Bioreagents provides NAGK antibody for metabolism and glycosylation research.
Experimentally, NAGK antibody is used in western blotting to detect the ~37 kDa enzyme, in immunohistochemistry to study tissue distribution, and in immunofluorescence to confirm cytoplasmic localization. Enzyme assays with NAGK antibody complement biochemical analyses of hexosamine pathway flux. -
UniProt
- Q9UJ70
抗原
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