RAI1 抗体 (AA 14-1906)
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北京 101111
Quick Overview for RAI1 抗体 (AA 14-1906) (ABIN7870617)
抗原
See all RAI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 14-1906
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原理
- RAI1 Antibody / Retinoic acid-induced protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human RAI1 recombinant protein (Position: Q14-P1906) was used as the immunogen for the RAI1 antibody.
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亚型
- IgG
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anti-Retinoic Acid Induced 1 (RAI1) (AA 617-823) antibody
RAI1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Retinoic Acid Induced 1 (RAI1) (AA 1-101) antibodyRAI1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 6H5 unconjugated
anti-Retinoic Acid Induced 1 (RAI1) (AA 25-75) antibodyRAI1 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the RAI1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RAI1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RAI1 (Retinoic Acid Induced 1 (RAI1))
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别名
- RAI1
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背景
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RAI1 antibody detects Retinoic acid-induced protein 1, a transcriptional regulator implicated in neurodevelopment, circadian rhythm control, and chromatin remodeling. RAI1 functions as a dosage-sensitive transcription factor that modulates neuronal gene expression and behavior. The RAI1 antibody is widely used in genetics, neurobiology, and developmental studies to explore transcriptional regulation and syndromic neurological disorders.
RAI1 is encoded by the RAI1 gene located on human chromosome 17p11.2. The protein is approximately 1906 amino acids in length and localizes predominantly to the nucleus, where it binds DNA and interacts with chromatin-modifying complexes. RAI1 acts as a transcriptional coactivator that influences gene networks involved in neuronal differentiation, circadian rhythm, and energy balance. Its expression is tightly controlled during embryonic development and in brain regions such as the hypothalamus and cortex.
The RAI1 antibody detects a 220 kilodalton band by western blot and reveals nuclear staining under immunofluorescence microscopy. Haploinsufficiency or deletion of RAI1 causes Smith-Magenis syndrome, characterized by developmental delay, sleep disturbances, and behavioral abnormalities. Conversely, duplication of the RAI1 region is associated with Potocki-Lupski syndrome, illustrating the gene's sensitivity to dosage imbalance.
RAI1 influences circadian rhythm through regulation of CLOCK and BMAL1 targets and modulates neuroplasticity and metabolic pathways. It may also interact with histone-modifying enzymes to alter chromatin accessibility. Dysregulation of RAI1 expression or mutation contributes to neuropsychiatric disorders including autism spectrum disorder, schizophrenia, and intellectual disability.
Because RAI1 governs transcriptional networks essential for neuronal function and rhythmic homeostasis, it serves as a vital link between chromatin dynamics and brain physiology. NSJ Bioreagents provides a validated RAI1 antibody optimized for its applications, supporting research into neurodevelopment, transcriptional control, and genomic disorders. -
UniProt
- Q7Z5J4
抗原
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