PAX8 抗体 (AA 137-450)
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北京 101111
Quick Overview for PAX8 抗体 (AA 137-450) (ABIN7870578)
抗原
See all PAX8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 137-450
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原理
- PAX8 Antibody / Paired box gene 8
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human PAX8 recombinant protein (Position: Q137-L450) was used as the immunogen for the PAX8 antibody.
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亚型
- IgG
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anti-Paired Box 8 (PAX8) antibody
KO Validated PAX8 适用: 人 WB, IHC, IF, IHC (p), ICC, IP, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Paired Box 8 (PAX8) (AA 60-261) antibodyPAX8 适用: 人, 犬 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal PAX8-1492 unconjugated
anti-Paired Box 8 (PAX8) (AA 60-261) antibodyPAX8 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1A1D3 unconjugated
anti-Paired Box 8 (PAX8) (AA 1-450) antibodyPAX8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H7 unconjugated
anti-Paired Box 8 (PAX8) (AA 60-261) antibodyPAX8 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal PAX8-1491 unconjugated
anti-Paired Box 8 (PAX8) (AA 300-377) antibodyPAX8 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D6 unconjugated
anti-Paired Box 8 (PAX8) (AA 141-250) antibodyPAX8 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Paired Box 8 (PAX8) (AA 300-377) antibodyPAX8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G11 unconjugated
anti-Paired Box 8 (PAX8) (N-Term) antibodyVerified PAX8 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Paired Box 8 (PAX8) (AA 300-450) antibodyPAX8 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3E6B3 unconjugated
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应用备注
- Optimal dilution of the PAX8 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PAX8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PAX8 (Paired Box 8 (PAX8))
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别名
- PAX8
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背景
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PAX8 antibody detects Paired box protein Pax-8, encoded by the PAX8 gene. Paired box protein Pax-8 is a transcription factor that plays a critical role in thyroid gland development, renal morphogenesis, and Mullerian duct differentiation. PAX8 antibody provides researchers with a vital reagent for studying transcriptional regulation, organogenesis, and tumor diagnostics.
PAX8 belongs to the paired box (PAX) family of transcription factors, which share a conserved DNA-binding paired domain. Research using PAX8 antibody has shown that it is essential for thyroid follicular cell development and regulates transcription of thyroid-specific genes including thyroglobulin and thyroperoxidase. These functions are crucial for thyroid hormone biosynthesis and endocrine regulation.
Studies with PAX8 antibody have revealed that PAX8 is also expressed in kidney and Mullerian duct-derived tissues, where it regulates organ formation and differentiation. This broad developmental role emphasizes its importance in multiple systems. PAX8 knockout mice display thyroid agenesis and renal malformations, demonstrating its essential developmental functions.
Dysregulation of Paired box protein Pax-8 has been associated with thyroid disease, infertility, and cancer. Research using PAX8 antibody has shown that PAX8 mutations contribute to congenital hypothyroidism and thyroid dysgenesis. In oncology, PAX8 is frequently expressed in thyroid carcinomas, renal cell carcinomas, and ovarian carcinomas, making it a reliable immunohistochemical marker for tumor diagnosis.
PAX8 antibody is widely applied in immunohistochemistry, western blotting, and chromatin immunoprecipitation. Immunohistochemistry highlights diagnostic expression in thyroid and renal tumors, western blotting quantifies protein levels, and ChIP studies identify DNA binding sites. These applications make PAX8 antibody indispensable in developmental biology and cancer pathology.
By providing validated PAX8 antibody reagents, NSJ Bioreagents supports studies into thyroid development, transcriptional regulation, and oncology. Detection of Paired box protein Pax-8 provides researchers with insight into how transcription factors govern organogenesis and disease. -
UniProt
- Q06710
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途径
- Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation
抗原
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