Neurogenin 3 抗体 (AA 137-214)
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北京 101111
Quick Overview for Neurogenin 3 抗体 (AA 137-214) (ABIN7870569)
抗原
See all Neurogenin 3 (NEUROG3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 137-214
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原理
- NEUROG3 Antibody / Neurogenin 3
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NEUROG3 recombinant protein (Position: Q137-L214) was used as the immunogen for the NEUROG3 antibody.
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亚型
- IgG
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anti-Neurogenin 3 (NEUROG3) (AA 40-69), (N-Term) antibody
NEUROG3 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB02913 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 1-101) antibodyNEUROG3 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 4E9 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 1-101) antibodyNEUROG3 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 4B7 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 1-83) antibodyNEUROG3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 61-160) antibodyNEUROG3 适用: 人, 小鼠, 大鼠, Pig WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurogenin 3 (NEUROG3) antibodyNEUROG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurogenin 3 (NEUROG3) (N-Term) antibodyNEUROG3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurogenin 3 (NEUROG3) antibodyNEUROG3 适用: 人 WB, IHC, IF 宿主: 小鼠 Monoclonal 3B5 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 1-214) antibodyNEUROG3 适用: 人 WB 宿主: 小鼠 Monoclonal 1800CT113-128-46 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 93-214) antibodyNEUROG3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NEUROG3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NEUROG3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Neurogenin 3 (NEUROG3)
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别名
- NEUROG3
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背景
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NEUROG3 antibody detects Neurogenin-3, encoded by the NEUROG3 gene. Neurogenin-3 is a basic helix-loop-helix transcription factor that plays a central role in the development of endocrine cells in the pancreas and intestine. NEUROG3 antibody provides researchers with a highly specific reagent for studying pancreatic development, endocrine lineage specification, and diabetes biology.
Neurogenin-3 regulates transcriptional networks that guide progenitor cells toward endocrine fates. Research using NEUROG3 antibody has shown that it activates genes required for insulin, glucagon, somatostatin, and pancreatic polypeptide production. In the intestine, it directs progenitors to form enteroendocrine cells, which secrete hormones critical for digestion and energy homeostasis. These findings emphasize its role as a master regulator of endocrine differentiation.
Studies with NEUROG3 antibody have revealed that mutations in NEUROG3 cause neonatal diabetes and congenital malabsorptive diarrhea. These conditions reflect failure of endocrine cell differentiation, leading to severe metabolic and gastrointestinal dysfunction. This demonstrates that Neurogenin-3 is indispensable for human development.
Beyond congenital disorders, research using NEUROG3 antibody has highlighted its role in regenerative biology. Activation of Neurogenin-3 in adult progenitors can stimulate endocrine differentiation, suggesting therapeutic strategies for diabetes through beta-cell regeneration. These findings expand the relevance of NEUROG3 from development to regenerative medicine.
NEUROG3 is also implicated in cancer. Abnormal expression has been detected in gastrointestinal tumors, where it may influence tumor differentiation. Research using NEUROG3 antibody continues to explore how developmental transcription factors become repurposed in oncogenesis.
NEUROG3 antibody is widely used in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry highlights endocrine progenitors in pancreatic tissue, western blotting quantifies protein levels in development and disease, and immunofluorescence demonstrates nuclear localization. These applications make NEUROG3 antibody indispensable in developmental biology and disease research.
By supplying validated NEUROG3 antibody reagents, NSJ Bioreagents supports studies into pancreatic and intestinal biology, diabetes, and cancer. Detection of Neurogenin-3 provides researchers with insight into how transcription factors regulate lineage specification and disease. -
UniProt
- Q9Y4Z2
抗原
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