TTDN1 抗体 (AA 135-179)
The 兔 多克隆 anti-TTDN1 antibody is suitable to detect TTDN1 in samples from 人. It has been validated for WB, ELISA, ICC 和 IF.
产品编号 ABIN7870539
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for TTDN1 抗体 (AA 135-179) (ABIN7870539)
抗原
See all TTDN1 (MPLKIP) 抗体
TTDN1 (MPLKIP)
(M-Phase Specific PLK1 Interacting Protein (MPLKIP))
适用
人
宿主
兔
克隆类型
多克隆
标记
This TTDN1 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
-
-
抗原表位
- AA 135-179
-
原理
- MPLKIP Antibody / M phase specific PLK1 interacting protein
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human MPLKIP recombinant protein (Position: E135-C179) was used as the immunogen for the MPLKIP antibody.
-
亚型
- IgG
-
-
anti-M-Phase Specific PLK1 Interacting Protein (MPLKIP) (AA 151-177), (C-Term) antibody
MPLKIP 适用: 人 WB 宿主: 兔 Polyclonal RB37478 unconjugated
anti-M-Phase Specific PLK1 Interacting Protein (MPLKIP) (Middle Region) antibodyMPLKIP 适用: 人, Cow, 犬, 豚鼠, 小鼠, 兔, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the MPLKIP antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the MPLKIP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- TTDN1 (MPLKIP) (M-Phase Specific PLK1 Interacting Protein (MPLKIP))
-
别名
- MPLKIP
-
背景
-
MPLKIP antibody is used to study M phase specific PLK1 interacting protein, a small nuclear protein that binds the mitotic kinase PLK1 and helps coordinate chromosome dynamics and cell cycle progression. By engaging Polo like kinase 1 during M phase, the protein contributes to proper spindle function and timely transition through mitosis, thereby preserving genome integrity. Beyond cell division, M phase specific PLK1 interacting protein participates in gene regulatory programs and has been linked to transcription-coupled processes that safeguard cell identity and stress adaptation.
The protein localizes to the nucleus and perinuclear regions, where it interfaces with chromatin and cell cycle machinery. Loss of function mutations in the MPLKIP gene, historically known as TTDN1, cause trichothiodystrophy non photosensitive type 1, a disorder characterized by brittle hair and developmental features, underscoring its role in nuclear homeostasis. Experimental systems suggest that M phase specific PLK1 interacting protein acts as a scaffold that positions kinases and effectors to ensure accurate phosphorylation timing, with downstream consequences for cohesion, condensation, and checkpoint signaling.
In the laboratory, researchers use MPLKIP antibody for immunoblotting to monitor expression across the cell cycle, for immunofluorescence to visualize nuclear patterns in interphase and mitosis, and for co-immunoprecipitation to examine complexes with PLK1 and associated regulators. When paired with synchronization, kinase inhibitors, or auxin-degron depletion, the antibody supports dissection of cause-and-effect relationships between protein abundance, phosphorylation events, and mitotic fidelity. In disease models, MPLKIP antibody enables evaluation of variant impact on stability and localization, clarifying genotype-phenotype mechanisms relevant to neurodevelopment and ectodermal biology.
The MPLKIP antibody from NSJ Bioreagents is optimized for consistent detection in common cell lines and primary cells, integrating with workflows that combine imaging, phospho-proteomics, and transcriptomics. By anchoring measurements of a PLK1-interacting scaffold, teams can connect mitotic control to transcriptional resets that follow cell division, and they can probe how nuclear organization influences tissue development and stress resilience. -
UniProt
- Q8TAP9
抗原
-
You are here:
